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Evaluation of chlorambucil therapy in steroid-dependent and cyclophosphamide-resistant children with nephrosis

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Abstract

A prospective study was performed to evaluate the efficacy of chlorambucil in inducing long-term remission in children with steroid-dependent or cyclophosphamide-resistant primary nephrotic syndrome (NS). The 15 steroid-dependent children had a relapse rate of 5.3/patient per year (range 4–8) and a mean age of 8.4 years (range 2–13). The chlorambucil dosage was 0.2 mg/kg per day for a total of 8 weeks. Nine patients (56%) remained in complete remission for an average of 39.2 months (range 16–70). The interval to the first relapse in the remaining 7 ranged from 4 to 41 months and the relapse rate decreased significantly to 0.6 relapses/patient per year (P<0.05). Five children had steroid- and cyclophosphamide-resistant NS, 4 with focal segmental glomerulosclerosis and 1 with mesangiol proliferative glomerulonephritis. Chlorambucil was given in a dose of 0.2 mg/kg per day for 8–16 weeks. Complete remission was obtained in 4 patients; 2 patients relapsed. No serious long-term complications were observed in our patients.

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Authors and Affiliations

  1. Department of Paediatrics, Faculty of Medicine, Kuwait University, PO Box 24923, Safat, Kuwait

    Abdelaziz Y. Elzouki

  2. Department of Paediatrics, Al Arab Medical University, Bengahzi, Libya

    O. P. Jaiswal

Authors
  1. Abdelaziz Y. Elzouki
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  2. O. P. Jaiswal
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Elzouki, A.Y., Jaiswal, O.P. Evaluation of chlorambucil therapy in steroid-dependent and cyclophosphamide-resistant children with nephrosis. Pediatr Nephrol 4, 459–462 (1990). https://doi.org/10.1007/BF00869820

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  • DOI: https://doi.org/10.1007/BF00869820

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