Enzymic and nonenzymic systems protecting photoreceptor membranes against active forms of oxygen and lipid peroxides
Activity of the enzyme systems protecting membrane structures of photoreceptor cells Ithe outer and inner segments of the retinal rods) against active forms of oxygen (superoxide dismutase) and lipid peroxide (glutathione peroxidase, glutathione reductase) was shown to be low. At the same time a high concentration of α-tocopherol (vitamin E) was demonstrated in these membranes. It is concluded that the polyene lipids of the retinal photoreceptors are protected against the harmful action of lipid peroxidation by the vitamin E system.
Key Wordssuperoxide dismutase glutathione peroxidase glutathione reductase α-tocopherol membranes of photoreceptors
Unable to display preview. Download preview PDF.
- 1.Yu. A. Vladimirov and A. I. Archakov, Peroxidation of Lipids in Biological Membranes [in Russian], Moscow (1972).Google Scholar
- 2.C. S. Foote, in: Free Radicals in Biology, Vol. 2, New York (1976), pp. 85–133.Google Scholar
- 3.L. V. Belousova, L. B. Bratkovskaya, I. V. Galushchenko, et al., Biokhimiya, No. 10, 1800 (1977).Google Scholar
- 4.V. E. Kagan, A. A. Shvedova, et al., Biofizika No. 6, 1043 (1975).Google Scholar
- 5.V. E. Kagan, G. V. Barybina, and K. N. Novikov, Byull. Éksp. Biol. Med., No. 4, 411 (1977).Google Scholar
- 6.M. V. Zueva, A. A. Shvedova, and O. I. Shcherbatova, Vestn. Oftal'mol., No. 3 56 (1977).Google Scholar
- 8.D. S. Papermaster and W. V. Dreyer, Biochemistry (Washington),13, 2438 (1971).Google Scholar
- 9.I. Fridovich, Account. Chem. Res.,5, 321 (1972).Google Scholar
- 10.V. Z. Lankin and S. M. Gurevich, Dokl. Akad. Nauk SSSR,226, 705 (1975).Google Scholar