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Role of histamine H2 receptors in the mechanism of formation of experimental gastric ulcers induced in rats by various stressors

  • Pathological Physiology and General Pathology
  • Published:
Bulletin of Experimental Biology and Medicine Aims and scope

Abstract

Dystrophic lesions of the gastric mucosa were observed to be formed and the pepsinogen content was reduced by 57% in the gastric mucosa of rats exposed to various experimental stressors (immobilization with electrical stimulation, immobilization at 6°C, trauma to or ligation of the pylorus). and the changes correlated with the degree of injury to the stomach. Pharmacological blockade of H2 receptors by cimetidine (100 μmoles/kg) and methiamide (410 μmoles/kg) largely prevented the formation of experimental ulcers and the decrease in the pepsinogen level. The results indicate that endogenous histamine participates in the mechanism of formation of dystrophic gastric lesions.

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Authors
  1. L. K. Gavroskaya
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  2. I. Yu. Agranovskaya
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Gavroskaya, L.K., Agranovskaya, I.Y. Role of histamine H2 receptors in the mechanism of formation of experimental gastric ulcers induced in rats by various stressors. Bull Exp Biol Med 88, 841–843 (1979). https://doi.org/10.1007/BF00869209

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  • DOI: https://doi.org/10.1007/BF00869209

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