Bulletin of Experimental Biology and Medicine

, Volume 88, Issue 2, pp 841–843 | Cite as

Role of histamine H2 receptors in the mechanism of formation of experimental gastric ulcers induced in rats by various stressors

  • L. K. Gavroskaya
  • I. Yu. Agranovskaya
Pathological Physiology and General Pathology


Dystrophic lesions of the gastric mucosa were observed to be formed and the pepsinogen content was reduced by 57% in the gastric mucosa of rats exposed to various experimental stressors (immobilization with electrical stimulation, immobilization at 6°C, trauma to or ligation of the pylorus). and the changes correlated with the degree of injury to the stomach. Pharmacological blockade of H2 receptors by cimetidine (100 μmoles/kg) and methiamide (410 μmoles/kg) largely prevented the formation of experimental ulcers and the decrease in the pepsinogen level. The results indicate that endogenous histamine participates in the mechanism of formation of dystrophic gastric lesions.

Key Words

histamine H2 receptors experimental gastric ulcers pepsinogen stress 


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Literature Cited

  1. 1.
    S. V. Anichkov, I. S. Zavodskaya, E. V. Moreva, et al., in: Neurogenic Dystrophies and Pharmacotherapy [in Russian], Leningrad (1969), p. 56.Google Scholar
  2. 2.
    S. V. Anichkov, The Selective Action of Mediators [in Russian] Leningrad (1974), p. 212.Google Scholar
  3. 3.
    L. L. Grechishkin and T. K. Mustafina, Byull. Éksp. Biol. Med., No. 3, 31 (1970).Google Scholar
  4. 4.
    I. S. Zavodskaya, Byull. Éksp. Biol. Med., No. 1, 26 (1954).Google Scholar
  5. 5.
    O. N. Zabrodin, Annual Report of the Institute of Experimental Medicine for 1961–1962 [in Russian], Vol. 7–8, Leningrad (1963), p. 212.Google Scholar
  6. 6.
    R. B. Strelkov, A Method of Calculating Standard Error and Confidence Intervals, of Arithmetic Means by Means of a Table [in Russian], Sukhumi (1966).Google Scholar
  7. 7.
    M. L. Anson and A. E. Myrsky, J. Gen. Physiol.,16, 69 (1932–1933).Google Scholar
  8. 8.
    R. I. Bersimbaev, S. V. Argutinskaya, and R. I. Salganik, Experientia,27, 1389 (1971).PubMedGoogle Scholar
  9. 9.
    J. Bugajski, J. Hano, and L. Danek, Eur. J. Pharmacol.,36, 237 (1976).PubMedGoogle Scholar
  10. 10.
    L. R. Dragstedt, in: Surgery of the Stomach and Duodenum, Boston (1962), p. 461.Google Scholar
  11. 11.
    L. L. Grechishkin, Pharmacology,13, 260 (1975).PubMedGoogle Scholar
  12. 12.
    D. J. Hetzel, G. J. Taggart, J. Hansky, et al., Med. J. Aust.,1, 317 (1977).PubMedGoogle Scholar
  13. 13.
    S. J. Konturek, T. Demitrescu, T. Radecki, et al., in: International Symposium on Histamine H2 Receptor Antagonists, London (1973), p. 247.Google Scholar
  14. 14.
    S. J. Konturek, T. Radecki, T. Demitrescu, et al., Digestion,10, 267 (1974).PubMedGoogle Scholar
  15. 15.
    C. Richardson, B. A. Bailey, J. Walsh, et al., J. Clin. Invest.,55, 536 (1975).PubMedGoogle Scholar

Copyright information

© Plenum Publishing Corporation 1980

Authors and Affiliations

  • L. K. Gavroskaya
  • I. Yu. Agranovskaya

There are no affiliations available

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