Human genetic diversity, a critical resource for man's future
- 31 Downloads
The human gene pool displays exuberant genetic variation; this is normal for a sexual species. Even small isolated populations contain a large percentage of the total variability, emphasizing the basic genetic unity of our species. As modern man spread across the world from its African source, the genetic basis for man's unique mental acuity was retained everywhere. Nevertheless, some geographical genetic variation such as skin color, stature and physiognomy was established. These changes were biologically relatively insignificant. Most of the ‘genetic load’ in the genome has been carried throughout the history of the species. There is little hope of purging all of these harmful genes; we must accept them and continue to treat their syndromes medically. All populations carry extensive genetic variation due to genes that encode variations in quantitative traits. Of greatest importance among these is ubiquitous polygenic variability in brain function and intelligence. Mental acuity is what sets us apart from the rest of the biological world. Throughout our history, genetic recombination among the many genes involved in brain function has occurred. This has provided a genetic basis for the action of natural selection that favors intelligence in meeting the demands of the environment. As environments change in the future, this type of genetic variability will continue to be a crucial resource.
Key WordsHuman evolution genetics of populations genetic load mutations quantitative genetics
Unable to display preview. Download preview PDF.
- Dobzhansky, Th.: 1964, ‘How do genetic loads affect the fitness of their carriers inDrosophila populations?’,American Naturalist 98, 151–166.Google Scholar
- Muller, H.J.: 1949, ‘Conceptions of Natural Selection’,Proceedings American Philosophical Society 93, 459–470.Google Scholar
- Muller, H.J.: 1950, ‘Our Load of Mutations’,American Journal Human Genetics 2, 111–176.Google Scholar
- Wallace, B: 1968,Topics in Population Genetics, W.W. Norton, New York.Google Scholar
- Wright, S.: 1932, ‘The Roles of Mutation, Inbreeding, Crossbreeding and Selection in Evolution’,Proceedings Sixth International Congress of Genetics 1, 356–366.Google Scholar
- Wright, S.: 1982, ‘Character Change, Speciation and the Higher Taxa’,Evolution 36, 427–443.Google Scholar