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Familial CNS tumors

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Summary

A family with central nervous system tumors in five individuals in two generations is reported. Of five sisters, two had an isolated meningioma and one an epen dymoma. Amongst the four children of those affected there was a son with two cerebral meningiomas and a daugther with a spinal meningioma. Signs typical of von Recklinghausen neurofibromatosis (NF1) or bilateral acoustic neurofibromatosis (NF2) were not present. The pattern is consistent with autosomal dominant inheritance with relatively high penetrance.

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Author notes

  1. Jörn P. Sieb

    Present address: Neuromuscular Research Laboratory, Department of Neurology, Mayo Clinic, 55905, Rochester, MN, USA

Authors and Affiliations

  1. Neurologische Universitätsklinik, Sigmund-Freud-Strasse 25, W-5300, Bonn 1, Germany

    Jörn P. Sieb & Anke Buch

  2. Division of Neurology, Cedars-Sinai Medical Center, University of California, Los Angeles, California, USA

    Stefan-M. Putst

Authors
  1. Jörn P. Sieb
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  2. Stefan-M. Putst
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  3. Anke Buch
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Sieb, J.P., Putst, SM. & Buch, A. Familial CNS tumors. J Neurol 239, 343–344 (1992). https://doi.org/10.1007/BF00867592

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  • DOI: https://doi.org/10.1007/BF00867592

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