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Peritoneal morphology in children treated by continuous ambulatory peritoneal dialysis

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Abstract

Fifty peritoneal biopsies (PB) from 35 patients with end-stage renal disease, treated by continuous ambulatory peritoneal dialysis (CAPD) and aged 2 months to 18 years, were examined by light microscopy (n=50) and/or scanning electron microscopy. PB were performed during surgical procedures immediately before the start of, during, or after the cessation of CAPD treatment. PB from 15 children without renal disease undergoing laparatomy were examined similarly. Before the start of CAPD, a scarcity and shortening of the mesothelial microvilli was observed by scanning electron microscopy. During and after CAPD, variable alterations of mesothelium, interstitium and capillaries were found. The mesothelial layer was absent in all 5 PB obtained during episodes of active peritonitis. In patients treated by CAPD for longer than 6 months, mesothelial denudation was observed more frequently (6/11) than in children treated for shorter periods (1/7) (P<0.08). Fibrosis of the peritoneal membrane was present in about 50% of patients during or after the cessation of CAPD without impairment of peritoneal function. No correlation was found between the presence of fibrosis and the frequency of peritonitis or the duration of CAPD treatment.

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Authors and Affiliations

  1. Department of Paediatrics, University of Heidelberg, Germany

    Fritz Schneble, Klaus-Eugen Bonzel & Karl Schärer

  2. Department of Pathology, University of Heidelberg, Germany

    Rüdiger Waldherr

  3. Department of Anatomy, University of Heidelberg, Germany

    Sebastian Bachmann

  4. Department of Paediatric Surgery, University of Heidelberg, Germany

    Helga Roth

Authors
  1. Fritz Schneble
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  2. Klaus-Eugen Bonzel
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  3. Rüdiger Waldherr
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  4. Sebastian Bachmann
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  5. Helga Roth
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  6. Karl Schärer
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Schneble, F., Bonzel, KE., Waldherr, R. et al. Peritoneal morphology in children treated by continuous ambulatory peritoneal dialysis. Pediatr Nephrol 6, 542–546 (1992). https://doi.org/10.1007/BF00866498

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  • DOI: https://doi.org/10.1007/BF00866498

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