IgA nephropathy and idiopathic thrombocytopenic purpura with splenectomy: a case report
A 14-year-old boy who had had a splenectomy at the age of 2 years for idiopathic thrombocytopenic purpura, suffered from IgA nephropathy. Serum IgA and IgE levels were elevated and low levels of circulating immune complexes were detected. Splenectomy may play a role in the pathogenesis or susceptibility to IgA nephropathy by means of decreased clearance of circulating immune complexes or impaired immune regulation, such as increased IgA synthesis.
Key wordsSplenectomy IgA nephropathy Immune complexes Idiopathic thrombocytopenic purpura Reticuloendothelial system
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