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Pediatric Nephrology

, Volume 7, Issue 2, pp 182–184 | Cite as

Disodium ethylenediaminetetraacetate: adverse effects in dialyzed children

  • Jorge A. Ramirez
  • William G. Goodman
  • Celine Menezes
  • Gino V. Segre
  • Isidro B. Salusky
Original Article

Abstract

The present report describes untoward effects of disodium ethylenediaminetetraacetate (EDTA) in three of six pediatric patients treated with continuous cycling peritoneal dialysis, in whom this agent was infused intravenously to lower serum ionized calcium levels during dynamic testing of parathyroid gland function. Patients developed an influenza-like syndrome characterized by fever rhinorrhea, cough, sneezing, and lacrimation. All symptoms disappeared within 24 h. A similar degree of hypocalcemia was induced with sodium citrate, an alternative hypocalcemic agent, in the same patients without side effects. Sodium citrate, rather than EDTA, should be used to induce hypocalcemia when assessing parathyroid gland dynamics in children with end-stage renal disease.

Key words

End-stage renal disease Hypocalcemia Parathyroid hormone stimulation Dialysis Sodium citrate Ethylenediaminetetraacetate 

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Copyright information

© IPNA 1993

Authors and Affiliations

  • Jorge A. Ramirez
    • 1
    • 2
    • 3
    • 4
  • William G. Goodman
    • 1
    • 2
    • 3
    • 4
  • Celine Menezes
    • 1
    • 2
    • 3
    • 4
  • Gino V. Segre
    • 1
    • 2
    • 3
    • 4
  • Isidro B. Salusky
    • 1
    • 2
    • 3
    • 4
  1. 1.Department of PediatricsUCLA School of Medicine, UCLA Medical CenterLos AngelesUSA
  2. 2.Department of MedicineUCLA School of Medicine, UCLA Medical CenterLos AngelesUSA
  3. 3.Department of Radiological SciencesUCLA School of Medicine, UCLA Medical CenterLos AngelesUSA
  4. 4.Endocrine Unit Massachusetts General HospitalHarvard Medical SchoolBostonUSA

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