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Plasma atrial natriuretic factor during cold-induced diuresis

European Journal of Applied Physiology and Occupational Physiology volume 67, pages 286–289 (1993)Cite this article

Summary

The purpose of this study was to evaluate the possible contribution of atrial natriuretic factor (ANF) to cold-induced diuresis. Seven healthy men, dressed in shorts, were exposed to a cold environment (+12°C) for 90 min, and also to a thermoneutral environment. Exposure to cold increased urine output and sodium excretion significantly but plasma ANF concentration remained unchanged. The increase in urinary potassium excretion during cold exposure was not significant (P=0.0636) and plasma renin activity did not change either. Exposure to cold increased mean arterial pressure significantly but it did not affect heart rate. We concluded that acute exposure to the cold environment induced a diuretic response, which was a solute diuresis in its nature. Our results did not give support to the hypothesis that ANF might be involved in the renal response to cold exposure.

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Authors and Affiliations

  1. Department of Anaesthesia, Helsinki University Central Hospital, Haartmaninkatu 4, SF-00290, Helsinki, Finland

    M. Hynynen

  2. Department of Physiology, Institute of Occupational Health, SF-00250, Helsinki, Finland

    R. Ilmarinen

  3. Fourth Department of Medicine, Helsinki University Central Hospital, SF-00170, Helsinki, Finland

    I. Tikkanen & F. Fyhrquist

Authors
  1. M. Hynynen
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  2. R. Ilmarinen
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  3. I. Tikkanen
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  4. F. Fyhrquist
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Hynynen, M., Ilmarinen, R., Tikkanen, I. et al. Plasma atrial natriuretic factor during cold-induced diuresis. Europ. J. Appl. Physiol. 67, 286–289 (1993). https://doi.org/10.1007/BF00864230

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  • DOI: https://doi.org/10.1007/BF00864230

Key words

  • Atrial natriuretic factor
  • Cold exposure
  • Diuresis
  • Urinary excretion
  • Renin activity