Skip to main content

Plasma atrial natriuretic factor during cold-induced diuresis

Summary

The purpose of this study was to evaluate the possible contribution of atrial natriuretic factor (ANF) to cold-induced diuresis. Seven healthy men, dressed in shorts, were exposed to a cold environment (+12°C) for 90 min, and also to a thermoneutral environment. Exposure to cold increased urine output and sodium excretion significantly but plasma ANF concentration remained unchanged. The increase in urinary potassium excretion during cold exposure was not significant (P=0.0636) and plasma renin activity did not change either. Exposure to cold increased mean arterial pressure significantly but it did not affect heart rate. We concluded that acute exposure to the cold environment induced a diuretic response, which was a solute diuresis in its nature. Our results did not give support to the hypothesis that ANF might be involved in the renal response to cold exposure.

This is a preview of subscription content, access via your institution.

References

  • Franco-Saenz R, Harper D, Mulrow PJ (1989) Effect of posture on the plasma levels of atrial natriuretic factor. Clin Exp Hypertens [A] 11:337–347

    Google Scholar 

  • Fregly MJ (1982) Water and electrolyte exchange during exposure to cold. Pharmacol Ther 18:199–231

    Google Scholar 

  • Fyhrquist F, Soveri P, Puutula L, Stenman U-H (1976) Radioimmunoassay of plasma renin activity. Clin Chem 22:250–256

    Google Scholar 

  • Fyhrquist F, Tikkanen I, Tötterman K-J, Hynynen M, Tikkanen T, Andersson S (1987) Plasma atrial natriuretic peptide in health and disease. Eur Heart J 8 [Suppl B]:117–122

    Google Scholar 

  • Granberg P-O (1991) Human physiology under cold exposure. Arctic Med Res 50 [Suppl 6]:23–27

    Google Scholar 

  • Hassi J, Rintamäki H, Ruskoaho H, Leppäluoto J, Vuolteenaho O (1991) Plasma levels of endothelin-1 and atrial natriuretic peptide in men during a 2-hour stay in a cold room. Acta Physiol Scand 142:481–485

    Google Scholar 

  • Hiramatsu K, Yamada T, Katakura M (1984) Acute effects of cold on blood pressure, renin-angiotensin-aldosterone system, catecholamines and adrenal steroids in man. Clin Exp Pharmacol Physiol 11:171–179

    Google Scholar 

  • Hynynen M, Kupari M, Salmenperä M, Tikkanen I, Heinonen J, Fyhrquist F, Tötterman KJ (1988) Hemodynamic effects of ahuman atrial natriuretic peptide in healthy volunteers. J Cardiovasc Pharmacol 11:711–715

    Google Scholar 

  • Hynynen M, Salmenpera M, Harjula ALJ, Tikkanen I, Fyhrquist F, Heinonen J (1990) Atrial pressure and hormonal and renal responses to acute cardiac tamponade. Ann Thorac Surg 49:632–637

    Google Scholar 

  • Ilmarinen R (1978) Einflüsse verschiedener Bekleidung auf einige physiologische Größen des Menschen bei Körperarbeit in unterschiedlich erhöhter Umgebungstemperatur und Luftfeuchtigkeit. Thesis, Deutsche Sporthochschule, Cologne

    Google Scholar 

  • Lennquist S (1972) Cold-induced diuresis. A study with special reference to electrolyte excretion, osmolal balance and hormonal changes. Scand J Urol Nephrol 6 [Suppl 9]:1–46

    Google Scholar 

  • Morgan ML, Anderson RJ, Ellis MA, Berl T (1983) Mechanism of cold diuresis in the rat. Am J Physiol 244:F210-F216

    Google Scholar 

  • Segar WE, Moore WW (1968) The regulation of antidiuretic hormone release in man. I. Effects of change in position and ambient temperature on blood ADH levels. J Clin Invest 47:2143–2151

    Google Scholar 

  • Tikkanen I, Fyhrquist F, Metsärinne K, Leidenius R (1985) Plasma atrial natriuretic peptide in cardiac disease and during infusion in healthy volunteers. Lancet II:66–69

    Google Scholar 

  • Vogelaere P, Savourey G, Deklunder G, Lecroart J, Brasseur M, Bekaert S, Bittel J (1992) Reversal of cold induced haemoconcentration. Eur J Appl Physiol 64:244–249

    Google Scholar 

  • Wagner JA, Horvath SM, Kitagawa K, Bolduan NW (1987) Comparisons of blood and urinary responses to cold exposures in young and older men and women. J Gerontol 42:173–179

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Hynynen, M., Ilmarinen, R., Tikkanen, I. et al. Plasma atrial natriuretic factor during cold-induced diuresis. Europ. J. Appl. Physiol. 67, 286–289 (1993). https://doi.org/10.1007/BF00864230

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00864230

Key words

  • Atrial natriuretic factor
  • Cold exposure
  • Diuresis
  • Urinary excretion
  • Renin activity