Journal of Neurology

, Volume 241, Issue 4, pp 242–245 | Cite as

Serum prolactin response to repetitive epileptic seizures

  • Jürgen Bauer
  • Petra Kaufmann
  • Dietrich Klingmüller
  • Christian E. Elger
Original Communication


We measured postictal prolactin (PRL) levels during repetitive seizures in 14 patients (10 men and 4 women) suffering from epilepsy with focal and/or secondarily generalized seizures. Between two and six seizures occurred per patient (mean 2.7). The interveral between seizures was 15 min and 8 h 40 min (mean 3 h 32 min). Five of the 14 patients showed a marked postictal PRL rise after each seizure (i.e. concentrations above 700 μU/ml for women, 500 μU/ml for men). In the remaining 9 patients there was no detectable rise in PRL. A decrease in PRL did not occur in any of the 14 patients. In those patients who had shown a marked PRL increase after the first seizure, the PRL continued to rise in subsequent seizures. Unlike previous investigations, these results show that repetitive epileptic seizures are not necessarily followed by a decrease in postical PRL levels. A decrease in PRL response is known to occur if there is progression to status epilepticus.

Key words

Epilepsy Prolactin Repetitive seizures Status epilepticus 


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Copyright information

© Springer-Verlag 1994

Authors and Affiliations

  • Jürgen Bauer
    • 1
  • Petra Kaufmann
    • 1
  • Dietrich Klingmüller
    • 2
  • Christian E. Elger
    • 1
  1. 1.Universitätsklinik für EpileptologieBonnGermany
  2. 2.Institut für Klinische BiochemieRheinische Friedrich-Wilhelms-Universität BonnBonnGermany

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