Pediatric Nephrology

, Volume 10, Issue 1, pp 76–78 | Cite as

Membranous nephropathy following perinatal transmission of hepatitis B virus infection—a long-term follow-up study

  • Micheline Levy
  • Marie-France Gagnadoux
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Abstract

In children with hepatitis B-associated membranous glomerulonephritis, the time of onset of the infection and the duration of the carrier state before diagnosis of the renal disease are always unknown. Moreover, followup is usually short. We report the unique observation of a French girl who was infected with hepatitis B virus by her mother who had acute hepatitis during the immediate postpartum period; the girl developed proteinuria at 6 years of age. The onset of the infection in the perinatal period, the mild liver abnormalities, and the absence of nephrotic syndrome did not justify any treatment. Spontaneous seroconversion to anti-HBe antibody positive occurred at 12 years of age. Proteinuria gradually diminished and was absent at 18 years. However, HBs antigenemia persits.

Key words

Membranous nephropathy Hepatitis B virus infection Vertical (or perinatal) transmission Low endemic country Perinatal period Seroconversion HBs antigen HBe antigen 

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References

  1. 1.
    Levy M, Chen N (1991) Worldwide perspective of hepatitis B-associated glomerulonephritis in the 80s. Kidney Int 40 [Suppl 35]: S-24–S-33Google Scholar
  2. 2.
    Gilbert RD, Wiggelinkhuizen J (1994) The clinical course of hepatitis B virus-associated nephropathy. Pediatr Nephrol 8: 11–14Google Scholar
  3. 3.
    Coovadia HM, Adhikari M, Moodley D (1993) Hepatitis B ‘s’ and ‘e’ antigen carriage in childhood nephrotic syndrome predicts membranous glomerulonephritis. Ann Trop Paediatr 13: 79–82Google Scholar
  4. 4.
    Seggie J, Nathoo K, Davies PG (1984) Association of hepatitis B antigenaemia and membranous glomerulonephritis in Zimbawean children. Nephron 38: 115–119Google Scholar
  5. 5.
    Lee HS, Choi Y, Yu SH, Koh HI, Kim MJ, Ko KW (1988) A renal biopsy study of hepatitis B virus associated nephropathy in Korea. Kidney Int 34: 537–543Google Scholar
  6. 6.
    Lin C-Y (1991) Clinical features and natural course of HBV-related glomerulopathy in children. Kidney Int 40 [Suppl 35]: S-46–S-53Google Scholar
  7. 7.
    Wong S-N, Yu E C-L, Chan K-W (1993) Hepatitis B virus associated membranous glomerulonephritis in children—experience in Hong Kong. Clin Nephrol 40: 142–147Google Scholar
  8. 8.
    Takekoshi Y, Tanaka M (1987) Hepatitis B virus-associated glomerulonephritis in children. In: Murakami K, Kitagawa T, Yabuta K, Saikai T (eds) Recent advances in pediatric nephrology, Elsevier, Amsterdam, pp 293–298Google Scholar
  9. 9.
    Madalinski K, Jung H, Stachowski J, Kossowski J (1991) Immunopathology of hepatitis B mediated membranous glomerulonephritis. Arch Immunol Ther Exp (Warsz) 39: 413–418Google Scholar
  10. 10.
    Locard-Bisot S, Cochat P, Gilly J, Parchoux B, Colon S, Rousson A, David L, Larbre F (1990) Glomérulonéphrites extramembraneuses chez l'enfant: 20 observations. Pediatrie 45: 527–532Google Scholar
  11. 11.
    Wouthwest Pediatric Nephrology Study Group (1985) Hepatitis B surface antigenemia in North American children with membranous glomerulonephropathy. J Pediatr 106: 571–578Google Scholar
  12. 12.
    Venkataseshan VS Lieberman K, Kim DU, Thung SN, Dikman S, Agati V d', Susin M, Valderrama E, Gauthier B, Prakash A, Churg J (1990) Hepatitis-B-associated glomerulonephritis: pathology, pathogenesis and clinical course. Medicine (Baltimore) 69: 200–216Google Scholar
  13. 13.
    Tong MJ (1990) The clinical consequences of perinatal infection of the hepatitis B virus. In: Coursaget P, Tong MJ (eds) Progress in hepatitis B immunization. Colloque INSERM, Libbey Eurotext Ltd, London, Vol 194: 3–10Google Scholar
  14. 14.
    Courouce AM (1990) Depistage de l'antigène HBs dans les dons de sang. Bull Epidémiologique Hebdomadaire 43: 183–184Google Scholar
  15. 15.
    Soalié J-C, Goudeau A, Larsen M, Parnet F, Dubois F, Pinon F, Huchet J, Brossard Y (1991) Prevention de la transmission périnatale du virus de l'hépatite B. Epidémiologie et rapport coût/efficacité dans la région de Paris. Presse Med 20: 939–944Google Scholar
  16. 16.
    Elidrissy ATH, Abdurrahman MB, Ramia S, Lynch JB (1988) Hepatitis B surface antigen associated nephrotic syndrome. Ann Trop Paediatr 8: 157–161Google Scholar
  17. 17.
    Cadrobbi P, Bortollotti F, Zachello G, Rinaldi R, Armigliato M, Realdi G (1985) Hepatitis B-virus replication in acute glomerulonephritis with chronic active hepatitis. Arch Dis Child 60: 583–585Google Scholar
  18. 18.
    Lai KN, Tam JS, Lin HS, Lai FM-M (1990) The therapeutic dilemma of the usage of corticosteroid in patients with membranous nephropathy and persistent hepatitis B virus antigenaemia. Nephron 54: 12–17Google Scholar
  19. 19.
    Garcia G, Scullard G, Smith C, Weissberg J, Alexander S, Robinson WS, Gregory P, Merigan TC (1985) Preliminary observation of hepatitis B-associated membranous glomerulonephritis treated with leukocyte interferon. Hepatology 5: 317–320Google Scholar
  20. 20.
    Mizushima N, Kanai K, Masuda H, Matsumoto M, Tamakoshi K, Ishii H, Nakajima T, Yoshimi T, Kimura M, Nagase M (1987) Improvement of proteinuria in a case of hepatitis B-associated glomerulonephritis after treatment with interferon. Gastroenterology 92: 524–526Google Scholar
  21. 21.
    Man RA de, Schalm SW, Heidjen AJ van der, Tate FWJ ten, Wolff ED, Heitjink RA (1989) Improvement of hepatitis B associated glomerulonephritis after antiviral combination therapy. J Hepatol 8: 367–372Google Scholar
  22. 22.
    Jonas MM, Ragin L, Silva MO (1991) Membranous glomerulonephritis and chronic persistent hepatitis B in a child. Treatment with recombinant interferon alfa. J Pediatr 119: 818–820Google Scholar
  23. 23.
    Wong S-N, Yu CL, Lok ASF, Chan K-W, Lau Y-L (1992) Interferon treatment for hepatitis B-associated membranous glomerulonephritis in two Chinese children. Pediatr Nephrol 6: 417–420Google Scholar
  24. 24.
    Gilboa N, Neigut D (1993) Interferon treatment of hepatitis B-associated membranous glomerulonephritis and nephrotic syndrome. Pediatr Nephrol 7: 328–329Google Scholar
  25. 25.
    Esteban R, Buti M, Vallès M, Allende H, Guardia J (1986) Hepatitis B-associated membranous glomerulonephritis treated with adenine arabinoside monophosphate. Hepatology 6: 762–764Google Scholar
  26. 26.
    Lin C-Y, Lo S (1991) Treatment of hepatitis B virus-associated membranous nephropathy with adenine arabinoside and thymic extract. Kidney Int 39: 301–306Google Scholar
  27. 27.
    Fonga-Djimi H, Gottrand F, Mazingue F, Farriaux JP (1993) Type B hepatitis and primary hepatocellular carcinoma in a nine-year-old French boy. Acta Paediatr 82: 1065Google Scholar
  28. 28.
    Giacchino R, Novone C, Facco F, Giambartolomei G, Pontisso P, Callea F (1991) HBV-DNA related hepatocellular carcinoma occurring in childhood. Hepatology 36: 1143–1146Google Scholar

Copyright information

© IPNA 1996

Authors and Affiliations

  • Micheline Levy
    • 1
  • Marie-France Gagnadoux
    • 2
  1. 1.Unité de Recherches d'Epidémiologie Génétique INSERM U. 155, Château de LongchampParisFrance
  2. 2.Department of Pediatric Nephrology and Unité de Recherches Rein en Développement et Néphropathies Héréditaires INSERM U. 423Necker-Enfants Malades HospitalParisFrance

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