Pediatric Nephrology

, Volume 10, Issue 1, pp 73–75 | Cite as

Nephrotic syndrome in a mother and her infant: relationship with cytomegalovirus infection

  • Marisa Giani
  • Alberto Edefonti
  • Beatrice Damiani
  • Giuseppina Marra
  • Daniela Colombo
  • Giovanni Banfi
  • Emilio Rivolta
  • Erich H. Strøm
  • Michael Mihatsch
Brief Report

Abstract

This case report describes infantile nephrotic syndrome (NS) in a baby girl with a clinically severe cytomegalovirus (CMV) infection. Culture of the baby's urine was positive for CMV and IgM anti-CMV antibodies were detected. After an unsuccessful course of corticosteroids, gancyclovir treatment was started and a remission of cutaneous, pulmonary, and renal symptoms was achieved. As the mother also developed NS at the end of pregnancy, a common etiology could be postulated, although there were no signs of recent CMV infection in the mother, only anti-CMV IgG. The relationship between CMV infection and glomerular disease is still unclear: NS may represent another manifestation of CMV disease.

Key words

Infantile nephrotic syndrome Cytomegalovirus infection Pregnancy 

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Copyright information

© IPNA 1996

Authors and Affiliations

  • Marisa Giani
    • 1
  • Alberto Edefonti
    • 1
  • Beatrice Damiani
    • 1
  • Giuseppina Marra
    • 1
  • Daniela Colombo
    • 1
  • Giovanni Banfi
    • 2
  • Emilio Rivolta
    • 2
  • Erich H. Strøm
    • 3
  • Michael Mihatsch
    • 3
  1. 1.Department of Pediatrics IIUniversity of MilanMilanItaly
  2. 2.Nephrology DivisionOspedale MaggioreMilanItaly
  3. 3.Institute of PathologyUniversity of BaselSwitzerland

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