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Synthesis of novel heterocycles from thiazolecarbohydrazides

  • V. A. Mamedov
  • I. A. Nuretdinov
  • F. G. Sibgatullina
Organic Chemistry Methods Of Synthesis

Abstract

Cyclization of 2-methyl (or -phenyl)-5-phenylthiazole-4-carbohydrazides (1) and (2) under various conditions gives differing oxadiazoles: 2-(2′-substituted-5′-phenyl-4′-thiazolyl)-1,3,4-oxadiazole-5-thiones (7) and (8), and 2-(2′-substituted-5′-phenyl-4′-thiazolyl)-1,3,4-oxadiazoles (9) and (10). Cyclodehydration of thiazolecarbonyl-thiosemicarbazides (3)–(6) with NaOH givesthe 3-(2′-substituted-5′-phenyl-4′-thiazolyl)-4-substituted-4H-5-mercapto-1,2,4-triazoles (11)–(14), while H 3 PO 4 gives the 2-(2′-substituted-5′-phenyl-4′-thiazolyl)-5-phenylamino-1,3,4-thiadiazoles (15) and (16).

Keywords

hydrazide thiosemicarbazide thiazole oxadiazole thiazole oxadiazole triazole thiadiazole 

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Copyright information

© Plenum Publishing Corporation 1992

Authors and Affiliations

  • V. A. Mamedov
  • I. A. Nuretdinov
  • F. G. Sibgatullina

There are no affiliations available

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