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Structure changes of the enterochromaffin cells of the small intestine of guinea pigs under the influence of rotundin

  • Morphology and Pathomorphology
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Bulletin of Experimental Biology and Medicine Aims and scope

Summary

A study was made on guinea pigs of both sexes of the histochemical changes in the enterochromaffin cells of the small intestine under the influence of the alkaloid rotundin. The Masson-Fontana method was used to investigate the state of the enterochromaffin cells. Argentophil granules of these cells have recently been identified with serotonin (5-hydroxytryptamine). Analysis of the data obtained showed that rotundin had a definite effect on the enterochromaffin cell system halving the number of these cells, and causing stimulation of the remainder to produce the morphological appearance of regenerating tissue. This evidence points to a possible role played by serotonin in the action of rotundin.

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Authors and Affiliations

  1. All-Union Scientific Research Institute of Therapeutic and Aromatic Plants, USSR Ministry of Health, Moscow

    I. V. Skorodumova & V. V. Berezhinskaya

Authors
  1. I. V. Skorodumova
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  2. V. V. Berezhinskaya
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Skorodumova, I.V., Berezhinskaya, V.V. Structure changes of the enterochromaffin cells of the small intestine of guinea pigs under the influence of rotundin. Bull Exp Biol Med 58, 865–867 (1964). https://doi.org/10.1007/BF00862703

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  • DOI: https://doi.org/10.1007/BF00862703

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