The pathomorphology of acute experimental toxoplasmosis produced by infection in various ways

Summary

An examination was carried out to investigate the pathology of changes induced in the golden hamster and albino mice infected with toxoplasma of the RH strain; the infection was made to resemble the natural routes as far as possible, and was made through the mouth, nose, conjunctiva, scarified skin, and mucosa of the genital tract; the material was fixed in 10% formalin, and stained in hematoxylin-eosin. The most acute infection followed transmission of the pathogens through the respiratory passages or through the mucosa of the genital tract. The acute course of the disease is determined by the degree of necrotic changes to the site of infection, and by the speed with it gains entrance into the blood causing a generalized infection, and death from alveoseptal pneumonia.