Summary
A study was made of changes in the rate of secretion in the supra-optic and paraventricular nuclei of rabbits in relation to thyroid concentration in the body. Changes in the hormonal balance were induced by thyroidectomy and by the administration of thyroidine or of 6-methylthiouracil.
Hypothalamic secretion in the control animals was fluctuating, i.e., a phase of secretion was followed by one of evacuation and a shift of the secretory granules into the neurohypophysis. Accordingly the main mass of neurosecretion was present either in the cells of the paraventricular and supra-optic nuclei and in the median eminence, or in the posterior hypophyseal lobe.
Treatment with thyroxin for 10 days led to an intensified production of the secretion in the hypothalamic nuclei, and to its accumulation in the neurohypophysis. Thyroidectomy or administration of 6-methylthiouracil decreased secretory activity by the cells, and caused a reduction in the store of neurosecretion in the posterior hypophyseal lobe.
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Zubkova-Mikhailova, E.I. Neurosecretion in the hypothalamic nuclei and the changes in the concentration of thyroid hormone. Bull Exp Biol Med 58, 853–857 (1964). https://doi.org/10.1007/BF00862700
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DOI: https://doi.org/10.1007/BF00862700