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Structure and reactivity in steroids

Communication 3. Kinetics of the oxidation of derivatives of 3,17β-estradiol and D-3,17αβ-homoestradiol
  • V. V. Egorova
  • A. V. Zakharychev
  • S. N. Ananchenko
  • I. V. Torgov
Physical Chemistry

Conclusions

  1. 1.

    An analysis was made of a previously proposed mechanism of the oxidation of secondary alcohols by CrO3 in CH3COOH; a formula was derived for the rate of this conversion under equilibrium conditions, and it was shown that the reactivity of the substrates can be characterized by two constants: thermodynamic and kinetic.

     
  2. 2.

    The kinetics of the oxidation of the 17β-OH group of derivatives of 3,17β-estradiol, D-3,17αβ-homoestradiol was studied, and it was shown that the experimental data satisfy the equation obtained.

     
  3. 3.

    A relationship was established between the reactivity of the 17β- and 17αβ-OH groups of estrogens as a function of the size of the D ring, the coupling of the B and C rings, and the electronic character of the substituent at C3.

     

Keywords

Oxidation Alcohol Experimental Data Steroid Estrogen 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Consultants Bureau 1971

Authors and Affiliations

  • V. V. Egorova
    • 1
  • A. V. Zakharychev
    • 1
  • S. N. Ananchenko
    • 1
  • I. V. Torgov
    • 1
  1. 1.Institute of the Chemistry of Natural CompoundsAcademy of Sciences of the USSRUSSR

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