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Regulation of cell function by extracellular matrix

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Abstract

The extracellular matrix (ECM) provides structural support and adhesive substrates for the body tissues. Recent advances in our understanding of the biology of matrix indicate that the ECM also plays a significant role in regulating the behavior of cells. Matrix proteins engender changes in cell shape and movement, bind growth factors, and facilitate cell-cell and cell-matrix interactions. Matrix-induced differentiation results from multiple stimuli that include: tensile forces on the cell, cytokine- or growth factor-mediated stimulation, and interaction with bioactive domains of matrix glycoproteins. Because these signals are important determinants of cell behavior, pharmacological manipulation of cell-matrix interactions may offer a valuable new approach to disease treatment.

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Authors and Affiliations

  1. Laboratory of Developmental Biology, National Institute of Dental Research, National Institute of Health, 111 Michigan Avenue NW., Bethesda, Maryland, USA

    H. William Schnaper & Hynda K. Kleinman

  2. Department of Nephrology, Children's National Medical Center, 111 Michigan Avenue NW., 20010, Washington, District of Columbia, USA

    H. William Schnaper

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  1. H. William Schnaper
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  2. Hynda K. Kleinman
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Schnaper, H.W., Kleinman, H.K. Regulation of cell function by extracellular matrix. Pediatr Nephrol 7, 96–104 (1993). https://doi.org/10.1007/BF00861587

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