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Non-immunological risk factors in paediatric renal transplantation

  • Practical Pediatric Nephrology
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Abstract

In paediatric renal transplantation, non-immunological risk factors account for about one-third of graft losses. Recurrence of original disease is observed mainly in primary hyperoxaluria and glomerulopathies such as steroid-resistant nephrotic syndrome and membranoproliferative glomerulonephritis. In both glomerulopathies, 20% of grafts are lost from recurrence. Vascular thrombosis is, in most series, the second cause of graft loss in children, particularly in young recipients or with young donors (under 5 years of age). Non-compliance with treatment is a common non-immunological factor in adolescent recipients, which may trigger a severe rejection process resulting in graft loss. The role of factors related to graft preservation and intra- and post-operative management (ischaemia time, delayed graft function) or to cytomegalovirus infection is less obvious in our series. Prevention of vascular thrombosis and of non-compliance is most important in order to improve the results of paediatric renal transplantation.

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  1. Department of Paediatric Nephrology, Hôpital des Enfants-Malades, 149 rue de Sèvres, F-75743, Paris Cedex 15, France

    Marie-France Gagnadoux, Patrick Niaudet & Michel Broyer

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  1. Marie-France Gagnadoux
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  2. Patrick Niaudet
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  3. Michel Broyer
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Gagnadoux, MF., Niaudet, P. & Broyer, M. Non-immunological risk factors in paediatric renal transplantation. Pediatr Nephrol 7, 89–95 (1993). https://doi.org/10.1007/BF00861586

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