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Tubulointerstitial nephritis in methylmalonic acidemia

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Abstract

We report two patients with methylmalonic acidemia (MMA) in whom renal biopsy demonstrated interstitial nephritis, bringing the total of such reported cases to four. In addition, hypertension, observed in one of our patients, has not been previously reported as the presentation of renal disease in MMA. The etiology of interstitial nephritis in MMA did not appear to be due to urate nephropathy. To date, 15 patients with MMA have been reported with renal complications, including chronic renal failure, making it imperative that children with MMA have their renal status evaluated.

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Authors and Affiliations

  1. Department of Pediatrics, University of Alabama at Birmingham, Alabama, USA

    S. Lane Rutledge & Ed Kohout

  2. Department of Pathology, The Children's Hospital, 1600 7th Avenue South, 35233, Birmingham, Alabama, USA

    Elizabeth Mroczek

  3. Department of Medicine, McGill University, Montreal, Quebec, Canada

    David Rosenblatt

  4. Department of Pediatrics, Johns Hopkins University, Baltimore, Maryland, USA

    Michael Geraghty

Authors
  1. S. Lane Rutledge
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  2. Michael Geraghty
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  3. Elizabeth Mroczek
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  4. David Rosenblatt
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  5. Ed Kohout
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Rutledge, S.L., Geraghty, M., Mroczek, E. et al. Tubulointerstitial nephritis in methylmalonic acidemia. Pediatr Nephrol 7, 81–82 (1993). https://doi.org/10.1007/BF00861581

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  • DOI: https://doi.org/10.1007/BF00861581

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