Abstract
A retrospective review of admission serum protein concentration in 18 children with hemolytic-uremic syndrome (HUS) showed significantly decreased serum total protein, albumin and globulin concentrations upon adminission compared with 22 matched controls (P<0.003). One child with atypical disease without diarrhea had normal serum protein concentrations. A strongly positive correlation (P=0.006) was found between the age of HUS patients with diarrhea and their lowest total protein concentrations. In 10 children who eventually required hemodialysis, there was a significantly negative correlation (r=−0.8316,P=0.01) between the admission serum albumin and the patients' highest creatinine levels, suggesting that hypoproteinemia may be a risk factor in the development of renal failure. The pathophysiological and clinical significance of hypoproteinemia in HUS needs further investigation.
References
Levin M, Barratt TM (1984) Hemolytic uremic syndrome. Arch Dis Child 59: 397–400
Gianatonio C, Vitacco M, Mendilaharzu F, Rutty A, Mendilaharzu J (1964) The hemolytic-uremic syndrome. J Pediatr 64: 478–491
Berman W (1972) The hemolytic uremic syndrome: initial clinical presentation mimicking ulcerative colitis. J Pediatr 81: 275–278
Waldmann TA, Wochner RD, Strober W (1969) The role of gastrointestinal tract in plasma protein metabolism. Am J Med 46: 77–79
Fried D, Gotlieh A, Zaidel L (1974) Intractable diarrhea of infancy. Arch Dis Child 127: 416–419
Kreisel C, Graben N, Pistor K, Feldhoff C (1983) Primäre intestinale Lymphangiektasie and rezidivierendes Hämolytisch Urämisches Syndrom. Med Welt 34: 655–657
Cimolai N, Carter JE, Morrison BJ, Anderson JD (1990) Risk factors for the progression ofEscherichia coli 0157: H7 enteritis to hemolytic-uremic syndrome. J Pediatr 116: 598–602
Cimolai N, Carter JE (1990) Influence of antidiarrheal and antimicrobial medications of the hemorrhagic colitis associated with hemolytic-uremic syndrome. J Pediatr 116: 589–592
Milford DV, Taylor CM (1990) New insights into the haemolytic uraemic syndromes. Arch Dis Child 65: 713–715
Loirat C, Sonsino E, Hinglais N, Jais JP, Landais P, Fermanian J (1988) Treatment of the childhood heamolytic uraemic syndrome with plasma. Pediatr Nephrol 2: 279–285
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Serebruany, V.L., Christenson, M.J., Pescetti, J. et al. Hypoproteinemia in the hemolytic-uremic syndrome of childhood. Pediatr Nephrol 7, 72–73 (1993). https://doi.org/10.1007/BF00861576
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00861576