Nitration of 2-aryl-3-hydroxypyridines

  • L. D. Smirnov
  • V. I. Kuz'min
  • V. P. Lezina
  • K. M. Dyumaev
Brief Communications

Conclusions

  1. 1.

    The authors have studied nitration of 2-(4′-alkylphenyl)-, 2-(4′-methoxyphenyl)-, and 2-(4′-chlorophenyl)-3-hydroxypyridines.

     
  2. 2.

    Using the PMR method, they show that the nitro group enters the meta position of the phenyl ring. With further nitration, the nitro group enters the 6 position of the pyridine ring.

     
  3. 3.

    Introduction of a hydroxy group into the pyridine ring facilitates nitration of the aryl substituent.

     

Keywords

Phenyl Pyridine Nitration Phenyl Ring Hydroxy Group 

Literature cited

  1. 1.
    L. D. Smirnov, V. I. Kuz'min, V. P. Lezina, and K. M. Dyumaev, Izv. Akad. Nauk SSSR, Ser. Khim., 1897 (1970).Google Scholar
  2. 2.
    H. Gilman and J. Edward, Canad. J. Chem.,37, 457 (1953).Google Scholar
  3. 3.
    J. W. Haworth, I. M. Heilbron, and D. H. Hey, J. Chem. Soc., 358 (1940).Google Scholar

Copyright information

© Consultants Bureau 1971

Authors and Affiliations

  • L. D. Smirnov
    • 1
  • V. I. Kuz'min
    • 1
  • V. P. Lezina
    • 1
  • K. M. Dyumaev
    • 1
  1. 1.Institute of Chemical PhysicsAcademy of Sciences of the USSRUSSR

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