Abstract
A 15-year-old boy developed minimal change nephrotic syndrome (MCNS) during remission of Hodgkin's disease. Natural killer (NK) cell activity was practically absent at the onset of MCNS, with a value of 3% compared with the normal value of 44.1%±7.8% (mean ± SD). Treatment with prednisolone resulted in transient remission of MCNs and partial improvement of NK cell activity. Extensive investigations for Hodgkin's disease were performed at 1- to 3-month intervals; a relapse finally became apparent 25 months after the diagnosis of MCNS. Successful treatment of Hodgkin's disease resulted in complete disappearance of proteinuria and normalisation of NK cell activity. Frequently relapsing MCNS with NK cells deficiency during remission of Hodgkin's disease appears to imply its subclinical relapse.
This is a preview of subscription content, log in via an institution to check access.
References
Eagan JW, Lewis EJ (1977) Glomerulopathies of neoplasia. Kidney Int 11: 297–306
Moorthy AV, Zimmerman SW, Burkholder PM (1976) Nephrotic syndrome in Hodgkin's disease. Evidence for pathogenesis alternative to immunecomplex deposition. Am J Med 61: 471–477
Plager J, Stutzman L (1971) Acute nephrotic syndrome as a manifestation of active Hodgkin's disease. Am J Med 50: 56–66
Walker F, O'Neil M, Carmody M, O'Dwyer WF (1983) Nephrotic syndrome in Hodgkins disease. Int J Pediatr Nephrol 4: 39–41
Komiyama A, Kawai H, Yabuhara A, Yanagisawa M, Miyagawa Y, Ota M, Hasekura H, Akabane T (1990) Natural killer cell immunodeficiency in siblings: defective killing in the absence of natural killer cytotoxic factor activity in natural killer and lymphokine-activated killer cytotoxicities. Pediatrics 85: 323–330
Kramer P, Sizoo W, Twiss EE (1981) Nephrotic syndrome in Hodgkin's disease. Neth J Med 24: 114–119
Gupta S, Fernandes G (1981) Spontaneous and antibody-dependent cellular cytotoxicity by lymphocyte subpopulations in peripheral blood and spleens from adult untreated patients with Hodgkin's disease. Clin Exp Immunol 45: 205–214
Kamiya H, Starr S, Lange B (1985) Natural killing in normal children and children with Hodgkin's disease. Am J Pediatr Hematol Oncol 7: 389–392
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Mori, T., Yabuhara, A., Nakayama, J. et al. Frequently relapsing minimal change nephrotic syndrome with natural killer cell deficiency prior to the overt relapse of Hodgkin's disease. Pediatr Nephrol 9, 619–620 (1995). https://doi.org/10.1007/BF00860957
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00860957