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P1 blood group antigen expression and epidemic hemolytic uremic syndrome

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Abstract

P1 blood group positivity has been postulated as a host factor which may provide protection against the development of post-enteropathic hemolytic uremic syndrome (HUS). In this study, blood group status in 20 Inuit survivors ofEscherichia coli 0157: H7-associated HUS was compared with age-and sex-matched controls from the same community who had experienced uncomplicated diarrheal illness due to the same pathogen. Of 20 HUS survivors, 6 were P1 antigen positive compared with 8 of the 20 controls (P=0.7). We conclude that P1 antigen positivity was not protective against HUS in this population. Further studies of this condition to clarify the role of host factors in verotoxin-induced endothelial damage are indicated.

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Authors and Affiliations

  1. Department of Community Health Sciences, University of Manitoba, Manitoba, Canada

    Pamela H. Orr & Victor Dong

  2. Department of Pediatrics and Child Health, University of Manitoba, Manitoba, Canada

    Marlis L. Schroeder & Malcolm R. Ogborn

  3. Canadian Red Cross Blood Transfusion Service, Winnipeg, Manitoba, Canada

    Marlis L. Schroeder

Authors
  1. Pamela H. Orr
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  2. Victor Dong
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  3. Marlis L. Schroeder
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  4. Malcolm R. Ogborn
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Orr, P.H., Dong, V., Schroeder, M.L. et al. P1 blood group antigen expression and epidemic hemolytic uremic syndrome. Pediatr Nephrol 9, 612–613 (1995). https://doi.org/10.1007/BF00860953

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  • DOI: https://doi.org/10.1007/BF00860953

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