Pediatric Nephrology

, Volume 9, Issue 5, pp 609–611 | Cite as

Effect of rifampin onStaphylococcus aureus colonization in children on chronic peritoneal dialysis

  • Coral D. Hanevold
  • Margaret C. Fisher
  • Rose Waltz
  • Sharon Bartosh
  • H. J. Baluarte
Brief Report


The efficacy of rifampin in eliminatingStaphylococcus aureus colonization was evaluated in a pediatric peritoneal dialysis population. Six children with documented nasal colonization were treated for 7 days with rifampin and cloxacillin. Although antimicrobial therapy eliminated nasal carriage in all patients, recolonization occurred in 66%. Exit site colonization proved difficult to eradicate with negative cultures documented in only 3 of 5 children after rifampin/cloxacillin therapy. AlthoughS. aureus carriage is a risk factor forS. aureus infections, efforts to eradicate carriage with rifampin are hindered by rapid recolonization.

Key words

Staphylococcus aureus Nasal carriage Peritonitis Exit site infection Peritoneal dialysis 


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Copyright information

© IPNA 1995

Authors and Affiliations

  • Coral D. Hanevold
    • 1
  • Margaret C. Fisher
    • 2
  • Rose Waltz
    • 1
  • Sharon Bartosh
    • 1
  • H. J. Baluarte
    • 1
  1. 1.Department of Pediatrics, Section of NephrologySt. Christopher's Hospital for Children and Temple University School of MedicinePhiladelphiaUSA
  2. 2.Section of Infectious DiseasesSt. Christopher's Hospital for Children and Temple University School of MedicinePhiladelphiaUSA

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