Abstract
The most well-described renal disease associated with hepatitis B virus (HBV) infection is membranous glomerulonephritis; membranoproliferative glomerulonephritis is described much less frequently. The course of HBV-associated renal disease after liver transplantation has not been described to date. We present a 15-year-old girl with HBV-associated membranoproliferative glomerulonephritis and end-stage liver disease, in whom, after cadaver liver transplantation, clinical and histological resolution of renal disease was observed. Resolution was associated with diminution of circulating HBV surface antigen levels.
Similar content being viewed by others
References
Combes B, Stastny P, Shorey J, Eigenbrodt EH, Barrera A, Hull AR, Carter NW (1971) Glomerulonephritis with deposition of Australia antigen-antibody complexes in glomerular basement membrane. Lancet II: 234–237
Johnson RJ, Couser WG (1990) Hepatitis B infection and renal disease: clinical, immunopathogenetic and therapeutic considerations. Kidney Int 37: 663–676
Venkataseshan VS, Lieverman K, Kim DU, Thung SN, Dikman S, D'Agati V, Susin M, Valderrama E, Gauthier B, Prakash A, Churg J (1990) Hepatitis B associated glomerulonephritis: pathology, pathogenesis, and clinical course. Medicine (Baltimore) 69: 200–216
Southwest Pediatric Nephrology Study Group (1985) Hepatitis B surface antigenemia in North American children with membranous glomerulonephropathy. J Pediatr 106: 571–578
Hsu HC, Wu CY, Lin CY, Lin GJ, Chen CH, Huang FY (1989) Membranous nephropathy in 52 hepatitis B surface antigen (HBsAg) carrier children in Taiwan. Kidney Int 36: 1103–1107
Lai KN, Lai FM (1991) Clinical features and the natural course of hepatitis B virus related glomerulopathy in adults. Kidney Int 40: S40-S45
Knecht GL, Chisari FV (1978) Reversibility of hepatitis B virus induced glomerulonephritis and chronic active hepatitis after spontaneous clearance of serum hepatitis B surface antigen. Gastroenterology 75: 1152–1156
Takekoshi Y, Tochimaru H, Nagata Y, Itami N (1991) Immunopathogenetic mechanisms of hepatitis B virus related glomerulopathy. Kidney Int 40: S34-S39
Iida Y, Izumino K, Asaka M, Kameyama T, Takata M, Mizumura Y, Sasayama S (1987) Membranoproliferative glomerulonephritis associated with chronic hepatitis B in adults: pathogenetic role of HBsAg. Am J Nephprol 7: 319–324
Ford DM, Briscoe DM, Shanley PF, Lum GM (1992) Childhood membranoproliferative glomerulonephritis type I: limited steroid therapy. Kidney Int 41: 1606–1612
Galanaud P, Crevon MC, Dormont J (1975) Effect of azathioprine on in vitro antibody response. Clin Exp Immunol 22: 139–152
Lai KN, Tam JS, Lin HJ, Lai FM (1990) The therapeutic dilemma of the usage of corticosteroid in patients with membranous nephropathy and persistent hepatitis B virus surface antigenaemia. Nephron 54: 12–17
Noble-Jamieson G, Thiru S, Johnston P, Friend P, Barnes ND (1992) Glomerulonephritis with end stage liver disease in childhood. Lancet 339: 706–707
Samuel D, Bismuth A, Mathieu D, Arulnaden JL, Reynes M, Benhamou JP, Brechot C, Bismuth H (1991) Passive immunoprophylaxis after liver transplantation in HBsAg positive patients. Lancet 337: 813–815
Todo S, Demetris AJ, Van Thiel D, Teperman L, Fung JJ, Starzl TE (1991) Orthotopic liver transplantation for patients with hepatitis B virus related liver disease. Hepatology 13: 619–626
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Quan, A., Portale, A., Foster, S. et al. Resolution of hepatitis B virus-related membranoproliferative glomerulonephritis after orthotopic liver transplantation. Pediatr Nephrol 9, 599–602 (1995). https://doi.org/10.1007/BF00860947
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00860947