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Resolution of hepatitis B virus-related membranoproliferative glomerulonephritis after orthotopic liver transplantation

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Abstract

The most well-described renal disease associated with hepatitis B virus (HBV) infection is membranous glomerulonephritis; membranoproliferative glomerulonephritis is described much less frequently. The course of HBV-associated renal disease after liver transplantation has not been described to date. We present a 15-year-old girl with HBV-associated membranoproliferative glomerulonephritis and end-stage liver disease, in whom, after cadaver liver transplantation, clinical and histological resolution of renal disease was observed. Resolution was associated with diminution of circulating HBV surface antigen levels.

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References

  1. Combes B, Stastny P, Shorey J, Eigenbrodt EH, Barrera A, Hull AR, Carter NW (1971) Glomerulonephritis with deposition of Australia antigen-antibody complexes in glomerular basement membrane. Lancet II: 234–237

    Google Scholar 

  2. Johnson RJ, Couser WG (1990) Hepatitis B infection and renal disease: clinical, immunopathogenetic and therapeutic considerations. Kidney Int 37: 663–676

    PubMed  Google Scholar 

  3. Venkataseshan VS, Lieverman K, Kim DU, Thung SN, Dikman S, D'Agati V, Susin M, Valderrama E, Gauthier B, Prakash A, Churg J (1990) Hepatitis B associated glomerulonephritis: pathology, pathogenesis, and clinical course. Medicine (Baltimore) 69: 200–216

    Google Scholar 

  4. Southwest Pediatric Nephrology Study Group (1985) Hepatitis B surface antigenemia in North American children with membranous glomerulonephropathy. J Pediatr 106: 571–578

    Google Scholar 

  5. Hsu HC, Wu CY, Lin CY, Lin GJ, Chen CH, Huang FY (1989) Membranous nephropathy in 52 hepatitis B surface antigen (HBsAg) carrier children in Taiwan. Kidney Int 36: 1103–1107

    PubMed  Google Scholar 

  6. Lai KN, Lai FM (1991) Clinical features and the natural course of hepatitis B virus related glomerulopathy in adults. Kidney Int 40: S40-S45

    Google Scholar 

  7. Knecht GL, Chisari FV (1978) Reversibility of hepatitis B virus induced glomerulonephritis and chronic active hepatitis after spontaneous clearance of serum hepatitis B surface antigen. Gastroenterology 75: 1152–1156

    PubMed  Google Scholar 

  8. Takekoshi Y, Tochimaru H, Nagata Y, Itami N (1991) Immunopathogenetic mechanisms of hepatitis B virus related glomerulopathy. Kidney Int 40: S34-S39

    Google Scholar 

  9. Iida Y, Izumino K, Asaka M, Kameyama T, Takata M, Mizumura Y, Sasayama S (1987) Membranoproliferative glomerulonephritis associated with chronic hepatitis B in adults: pathogenetic role of HBsAg. Am J Nephprol 7: 319–324

    Google Scholar 

  10. Ford DM, Briscoe DM, Shanley PF, Lum GM (1992) Childhood membranoproliferative glomerulonephritis type I: limited steroid therapy. Kidney Int 41: 1606–1612

    PubMed  Google Scholar 

  11. Galanaud P, Crevon MC, Dormont J (1975) Effect of azathioprine on in vitro antibody response. Clin Exp Immunol 22: 139–152

    PubMed  Google Scholar 

  12. Lai KN, Tam JS, Lin HJ, Lai FM (1990) The therapeutic dilemma of the usage of corticosteroid in patients with membranous nephropathy and persistent hepatitis B virus surface antigenaemia. Nephron 54: 12–17

    PubMed  Google Scholar 

  13. Noble-Jamieson G, Thiru S, Johnston P, Friend P, Barnes ND (1992) Glomerulonephritis with end stage liver disease in childhood. Lancet 339: 706–707

    PubMed  Google Scholar 

  14. Samuel D, Bismuth A, Mathieu D, Arulnaden JL, Reynes M, Benhamou JP, Brechot C, Bismuth H (1991) Passive immunoprophylaxis after liver transplantation in HBsAg positive patients. Lancet 337: 813–815

    PubMed  Google Scholar 

  15. Todo S, Demetris AJ, Van Thiel D, Teperman L, Fung JJ, Starzl TE (1991) Orthotopic liver transplantation for patients with hepatitis B virus related liver disease. Hepatology 13: 619–626

    PubMed  Google Scholar 

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Quan, A., Portale, A., Foster, S. et al. Resolution of hepatitis B virus-related membranoproliferative glomerulonephritis after orthotopic liver transplantation. Pediatr Nephrol 9, 599–602 (1995). https://doi.org/10.1007/BF00860947

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  • DOI: https://doi.org/10.1007/BF00860947

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