Skip to main content
Log in

The intravenous urogram in the detection and evaluation of renal damage following urinary tract infection

  • Practical Pediatric Nephrology
  • Published:
Pediatric Nephrology Aims and scope Submit manuscript

Abstract

Intravenous urography (IVU) still provides the most comprehensive structural assessment of the urinary tract. In particular, the radiological renal appearances approximate closely to the morphology of the renal scarring of reflux nephropathy or chronic atrophic pyelonephritis. It also provides reproducible renal measurements for followup assessment of renal growth and scarring. It is now less often used for first-line investigation of the acute urinary tract infection (UTI) because the swelling accompanying acute renal involvement is less eacognised than the areas of defective function demonstrated on99mtechnetiumdimercaptosuccinic acid (DMSA) studies. Also IVU contributes a higher radiation dose when calculated for full IVU (dependent on the number of films exposed) and there is a slight risk of side effects from injected contrast media, reduced by using non-ionic compounds. Because of its value in confirming such a serious diagnosis as renal scarring, suspected on ultrasonography or DMSA scintigraphy, modification of the technique of IVU with adequate preparation and the use of a reduced number of films, or single films localised to the renal areas, should be considered. Expertise in the interpretation of IVU must also be maintained because of the ancillary information regarding bowel and bladder function, the spine and evidence of stones, pertinent to the management of children with UTI and renal scarring. IVU and DMSA study remain complementary investigations.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  1. Smellie JM, Normand ICS, Katz G (1981) Children with urinary tract infection: a comparison of those with and those without vesico-ureteric reflux. Kidney Int 20:717–722

    Google Scholar 

  2. Smellie JM, Edwards D, Hunter N, Normand ICS, Prescod N (1975) Vesico-ureteric reflux and renal scarring. Kidney Int 8:S65-S72

    Google Scholar 

  3. Chantler C, Carter JE, Bewick M, Coupahan, R, Cameron JS, Ogg CS, Williams DG, Winder E (1980) 10 years' experience with regular haemodialysis and renal transplantation. Arch Dis Child 55:435–445

    Google Scholar 

  4. Schärer K (1987) Hypertension in children and adolescents 1986. Pediatr Nephrol 1:50–58

    Google Scholar 

  5. Becker CJ, Ihle BV, Bastos M, Kincaid-Smith P (1986) Effect of pregnancy on moderate renal failure in reflux nephropathy. BMJ 293:796–798

    Google Scholar 

  6. Heptinstall RH (1992) Pyelonephritis: pathologic features In: Heptinstall RH (ed) Pathology of the kidney. 4th edn. Little Brown, Boston, pp 1489–1561

    Google Scholar 

  7. Risdon RA (1994) Pyelonephritis and reflux nephropathy. In: Tisher CC, Brenner IM (eds) Renal pathology with clinical and functional correlation. Lippincott, Philadelphia, pp 832–862

    Google Scholar 

  8. Hodson CJ (1959) The radiological diagnosis of pyelonephritis. Proc R Soc Med 52:669–672

    Google Scholar 

  9. Edwards D, Normand ICS, Prescod N, Smellie JM (1977) The disappearance of vesico-ureteric reflux during long-term prophylaxis of urinary tract infection in children. BMJ 2:285–288

    Google Scholar 

  10. Hodson CJ (1979) Ruflux nephropathy: scoring the damage. In: Hodson J, Kincaid-Smith P (eds) Reflux nephropathy. Masson, New York, pp 29–47

    Google Scholar 

  11. Risdon RA (1993) The small scarred kidney in childhood. Pediatr Nephrol 7:361–364

    Google Scholar 

  12. Risdon RA, Yeung CK, Ransley PG (1993) Reflux nephropathy in children submitted to unilateral nephropathy; a clinico-pathological study. Clin Nephrol 40:308–313

    Google Scholar 

  13. Smellie JM, Daman Willems CE (1989) Vesico-ureteric reflux: recent research and its effect upon clinical practice In: Catto GRD (ed) Urinary tract infection 3 (new clinical applications: nephrology) Kluwer, Lancaster, pp 39–86

    Google Scholar 

  14. Winberg J, Bollgren I, Källenius G, Möllby R, Svenson SB (1982) Clinical pyelonephritis and focal renal scarring Pediatr Clin North Am 29:801–813

    Google Scholar 

  15. Winter AL, Hardy BE, Alton DJ, Arbus GS, Churchill BM (1983) Acquired renal scars in children. J Urol 129:1190–1194

    Google Scholar 

  16. Smellie JM, Ransley PG, Normand ICS, Prescod, N, Edwards D (1985) Development of new scars: a collaborative study. BMJ 295: 237–241

    Google Scholar 

  17. Saxton HM (1969) Review article: urography. Br J Radiol 42:321–346

    Google Scholar 

  18. Lebowitz RL (1985) Pediatric Uroradiology. Pediatr Clin North Am 32:1353–1361

    Google Scholar 

  19. Dawson P (1990) Intravenous urography revisited. Br J Urol 66:561–567

    Google Scholar 

  20. Teplick JG, Teplick SK, Berinson H, Haskin ME (1978) Urographic and angiographic changes in acute unilateral pyelonephritis. Clin Radiol 30:59–66

    Google Scholar 

  21. Tappin DM, Murphy AV, Mocan H, Shaw R, Beattie TJ, McAllister TA, MacKenzie R (1989) Acta Paediatr Scand 78:923–929

    Google Scholar 

  22. Melis K, Vandevivere J Hoskens C, Vervaet A, Sand A, Van Acker KJ (1992) Involvement of the renal parenchyma in acute urinary tract infection: the contribution of99mTc dimercapto-succinic acid scan. Eur J Pediatr 151:536–539

    Google Scholar 

  23. Sty JR, Wells RG, Starshak RJ, Schroeder BA (1987) Imaging in acute renal infection in children. AJR 148:471–477

    Google Scholar 

  24. Rushton HG, Majd M (1992) Dimercaptosuccinic acid renal scintigraphy for the evaluation of pyelonephritis and scarring: a review of experimental and clinical studies. J Urol 148: 1726–1732

    Google Scholar 

  25. Johansson B, Troell S, Berg U (1988) Renal parenchymal volume during and after acute pyelonephritis measured by ultrasonography. Arch Dis Child 63:1309–1314

    Google Scholar 

  26. Wikstad I, Hannerz L, Karlsson A, Eklof A-C, Olling S, Aperia A (1990)99mTechnetium dimercaptosuccinic acid scintigraphy in the diagnosis of acute pyelonephritis in rats. Pediatr Nephrol 4:331–334

    Google Scholar 

  27. Ransley PG, Risdon RA (1981) Reflux nephropathy: effects of antimicrobial therapy on the evolution of the early pyelonephritic scar. Kidney Int 20:733–742

    Google Scholar 

  28. Eklöf A-C, Ringertz H (1981) Kidney size in children, a method of assessment. Acta Radiol 17:1617–1627

    Google Scholar 

  29. Klare B, Geiselhardt B, Wesch H, Schärer K, Immich H, willich E (1980) Radiological kidney size in childhood. Pediatr Radiol 9:153–160

    Google Scholar 

  30. Hodson CJ, Davies Z, Prescod A (1975) Renal parenchymal radiographic measurements in infants and children. Pediatr Radiol 3:16–19

    Google Scholar 

  31. Claesson I, Jacobsson B, Olsson T, Ringertz H (1981) Assessment of renal parenchymal thickness in normal children. Acta Radiol Diagn 22:305–314

    Google Scholar 

  32. Herbetko J, Hyde I (1990) Urinary tract dilatation in constipated children. Br J Radiol 63:855–857

    Google Scholar 

  33. Sherwood T (ed) (1975) Uroradiology. Blackwell, Oxford pp 144–145

    Google Scholar 

  34. Smellie JM (1989) Bacteriuria in childhood: recognition of those at risk of renal scarring. In: Kass EH, Svanborg-Edén C (eds) Host-parasite interactions in urinary tract infection. Proceedings of the 4th International Symposium on Pyelonephritis. University of Chicago Press, Chicago, pp 258–264

    Google Scholar 

  35. Shrimpton PC, Wall BF, Jones DG et al (1986) A national survey of doses to patients undergoing a selection of routine X-ray examinations in English hospital. National Radiological Protection Board R200 HMSO, London

    Google Scholar 

  36. Administration of Radioactive Substance Advisory Committee (1993) Notes for guidance on the administration of radioactive substances. Dept. of health, London

    Google Scholar 

  37. Smellie JM, Edwards D, Normand ICS, Prescod N (1981) The effect of vesico-ureteric reflux on renal growth in children with urinary tract infection. Arch Dis Child 56:593–598

    Google Scholar 

  38. International Reflux Study Committee Report (1981) Medical versus surgical treatment of primary vesicoureteral reflux. Pedia trics 67:392–400

    Google Scholar 

  39. Klare B, Schärer K (1987) Long-term follow-up of kidney growth and split renal function in children with urinary tract infections with and without vesicoureteral reflux. In: Kass EH Svanborg-Edén C (eds) Host-parasite interactions in urinary tract infections. Proceedings of the 4th International Symposium on Pyelonephritis. University of Chicago Press, Chicago, pp 265–273

    Google Scholar 

  40. Katayama H, Yamaguchi K, Kozuka T, Takashima T, Seez P, Matsuura K (1990) Adverse reactions to ionic and nomonic contrast media: a report from the Japanese Committee on the Safety of Contrast Media. Radiology 175:621–628

    Google Scholar 

  41. Lalli AF (1980) Contract media reactions: data analysis and hypothesis. Radiology 134:1–12

    Google Scholar 

  42. Jakobsson B, Nolstedt L, Svensson L, Söderlundh S, Berg U (1992)99m Technetium-dimercaptosuccinic acid scan in the diagnosis of acute pyelonephritis in children: relation to clinical and radiological findings. Pediatr Nephrol 6:328–334

    Google Scholar 

  43. Risdon RA, Godley ML, Gordon I, Ransley PG (1994) Renal pathology and the99mTc-DMSA image before and after treatment of the evolving pyelonephritic scar: an experimental study. J Urol 152:1260–1266

    Google Scholar 

  44. Arnold AJ, Brownless SM, Carty HM, Rickwood AMK (1990) Detection of renal scarring by DMSA scanning — an experimental study. J Pediatr Surg 25:391–393

    Google Scholar 

  45. Smellie JM, Shaw PJ, Prescod NP, Bantock HM (1988)99mTc dimercaptosuccinic acid (DMSA) scan in patients with established renal scarring. Arch Dis Child 63:1315–1319

    Google Scholar 

  46. Goldraich NP, Ramos OL, Goldraich IH (1989) Urography versus DMSA scan in children with vesicoureteric reflux. Pediatr Nephrol 3:1–5

    Google Scholar 

  47. McLorie GA, Aliabadi H, Churchill BM, Ash JM, Gilday DA (1989)99mTechnetium-dimercapto-succinic acid renal scanning and excretory urography in diagnosis of renal scars in children. J Urol 142:790–792

    Google Scholar 

  48. International Reflux Study in Children: European Group (1992) Five year study of medical and surgical treatment in children with severe reflux: radiological renal findings. Pediatr Nephrol 6:223–230

    Google Scholar 

  49. Piepz A, Tamminen-Möbius T (1990) Correlation between scintigraphic lesions and renal scarring in intravenous urogram in children with normal relative uptake of DMSA and evaluation of normal kidney findings of DMSA scan. Contrib Nephrol 79: 147–155

    Google Scholar 

  50. Smellie JM, Prescod N, Shaw P, Bantock H, Normand ICS (1989) Comparison of radiology and nuclear imaging in the assessment of patients with renal scarring. In Kass EH, Svanborg-Edén C (eds) Host-parasite interactions in urinary tract infections. Proceedings of the 4th International Symposium on Pyelonephritis. University of Chicago Press, Chicago, pp 280–284

    Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Smellie, J.M. The intravenous urogram in the detection and evaluation of renal damage following urinary tract infection. Pediatr Nephrol 9, 213–219 (1995). https://doi.org/10.1007/BF00860753

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF00860753

Key words

Navigation