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Tubulointerstitial nephritis and uveitis: an immunological disorder?

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Abstract

A 14-year-old boy with tubulointerstitial nephritis and uveitis (TINU syndrome) is described. Nephropathy improved without systemic cortisone treatment, whereas uveitis relapsed and was treated with topical steroids. Blood cell immunological analysis and serum analysis revealed signs of cytotoxic T-cell, macrophage and granulocyte activation, which declined as the clinical symptoms improved. This may be interpreted as an indication of their significance as markers in the pathogenesis of this syndrome or as part of a microbial-triggered immune response.

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References

  1. Dobrin RS, Venier RL, Fish AL (1975) Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome. Am J Med 59: 325–333

    Google Scholar 

  2. Kikkawa Y, Sakurai M, Mano T, Hirabayashi K, Kitagawa T (1977) Interstitial nephritis with concomitant uveitis. Contrib Nephrol 4: 1–11

    Google Scholar 

  3. Van Acker KJ, Buysens N, Nectens A, Lequesne M, Desmet N (1980) Acute tubulointerstitial nephritis with uveitis. Acta Paediatr Belg 33: 171–177

    Google Scholar 

  4. Steinman TI, Silva P (1984) Acute interstitial nephritis and iritis. Renal ocular syndrome. Am J Med 77: 189–191

    Google Scholar 

  5. Vanhaesebrouck P, Carton D, De Belle C, Praet M, Proesmans W (1985) Acute tubulo-interstitial nephritis and uveitis syndrome (TINU syndrome). Nephron 40: 418–422

    Google Scholar 

  6. Ilda H, Terada Y, Nishino A, Takata M, Mitsumura Y, Sugimoto T, Kubota S (1985) Acute interstitial nephritis with bone marrow granulomas and uveitis. Nephron 40: 108–112

    Google Scholar 

  7. Burnier M, Jaeger P, Campiche M, Wauters JP (1986) Idiopathic acute interstitial nephritis and uveitis in the adult. Am J Nephrol 6: 312–315

    Google Scholar 

  8. Gafter U, Ben-Basat M, Zevin D, Komlos I, Savir H, Levi J (1986) Anterior uveitis, a presenting symptom in acute interstitial nephritis. Nephron 42: 249–251

    Google Scholar 

  9. Rosenbaum JT (1988) Bilateral anterior uveitis and interstitial nephritis. Am J Ophthalmol 105: 534–537

    Google Scholar 

  10. Hirano K, Tomino Y, Mikami H, Ota K, Aikawa Y, Shirato I, Kuide H (1989) A case of acute tubulointerstitial nephritis and uveitis syndrome with a dramatic response to corticosteroid therapy. Am J Nephrol 9: 499–503

    Google Scholar 

  11. Yoshioka K, Takemura T, Kanasaki M, Akano N, Maki S (1991) Acute interstitial nephritis and uveitis syndrome: activated immune cell infiltration in the kidney. Pediatr Nephrol 5: 232–234

    Google Scholar 

  12. Igarashi T, Kawato H, Kamushita S, Nosaka K, Seiya K, Hayakawa H (1992) Acute tubulointerstitial nephritis with uveitis syndrome presenting as multiple tubular dysfunction including Fanconi syndrome. Pediatr Nephrol 6: 547–549

    Google Scholar 

  13. Bunchman TE, Bloom JN (1993) A syndrome of acute interstitial nephritis and anterior uveitis. Pediatr Nephrol 7: 520–522

    Google Scholar 

  14. Ellis D, Fried WA, Yunis EJ, Blau EB (1981) Acute interstitial nephritis in children: a report of 13 cases and review of the literature. Pediatrics 67: 862–870

    Google Scholar 

  15. Drachman R, Schlesinger M, Shapira H, Drukker A (1989) The immune status of uraemic children/adolescents with chronic renal failure and renal replacement therapy. Pediatr Nephrol 3: 305–308

    Google Scholar 

  16. Uchiyama T, Nelson DL, Fleisher TA, Waldman TA (1981) A monoclonal antibody (anti-Tac) reactive with activated and functionally mature human T cells. II. Expression of Tac antigen on activated cytotoxic killer T cells, suppressor cells and on one of two types of helper T cells. J Immunol 126: 1398–1403

    Google Scholar 

  17. Rubin LA, Kurman CC, Fritz ME, Biddison WE, Boutin B, Yarchoan R, Nelson DL (1985) Soluble interleukin 2 receptors are released from activated human lymphoid cells in vitro. J Immunol 135: 3172–3177

    Google Scholar 

  18. Ware CF, Crowe PD, Vanrsdale TL, Andrews JL, Grayson MH, Jerzy R, Smith CA, Goodwin RG (1991) Tumor necrosis factor (TNF) receptor expression in T lymphocytes. J Immunol 147: 4229–4238

    Google Scholar 

  19. Imamura K, Spriggs D, Kufe D (1987) Expression of tumor necrosis factor receptors on human monocytes and internalization of receptor bound ligand. J Immunol 139: 2989–2994

    Google Scholar 

  20. Fuchs D, Hausen A, Reibnegger G, Werner ER, Dierich MP, Wachter H (1992) Neopterin as a marker for activated cell-mediated immunity: application in HIV-infection. Immunol Today 9: 150–155

    Google Scholar 

  21. Anderson CL, Looney RJ (1986) Human leukocyte IgG Fe receptors. Immunol Today 7: 264–266

    Google Scholar 

  22. Van de Winkel JGJ, Anderson CL (1991) Biology of human immunoglobulin G Fc receptors. J Leukoc Biol 49: 411–524

    Google Scholar 

  23. Rose NR, Herskowitz A, Neumann DA, Neu N (1988) Auto-immune myocarditis: a paradigm of post-infection autoimmune disease. Immunol Today 9: 117–122

    Google Scholar 

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Authors and Affiliations

  1. Department of Paediatrics, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria

    R. Birnbacher, E. Balzar & E. Förster

  2. Department of Internal Medicine III, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria

    C. Aufricht & S. Schmaldienst

  3. Department of Ludwig Boltzmann Institute of Experimental Endocrinology, University of Vienna, Währinger Gürtel 18-20, A-1090, Vienna, Austria

    W. Woloszczuk

Authors
  1. R. Birnbacher
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  2. E. Balzar
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  3. C. Aufricht
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  4. S. Schmaldienst
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  5. W. Woloszczuk
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  6. E. Förster
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Birnbacher, R., Balzar, E., Aufricht, C. et al. Tubulointerstitial nephritis and uveitis: an immunological disorder?. Pediatr Nephrol 9, 193–195 (1995). https://doi.org/10.1007/BF00860744

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  • DOI: https://doi.org/10.1007/BF00860744

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