Abstract
Patients maintained on chronic peritoneal dialysis (CPD) have been reported to have a variety of abnormalities of humoral immunity, including hypogammaglobulinemia, altered response to vaccination, and selective absence of IgG2. We measured serum immunoglobulin and IgG subclass levels in 22 pediatric CPD patients followed at our institution; 8 patients had low total IgG; 4 of these had low levels of IgG2 and 3 also had low IgG1, but IgG2 levels were detected in all patients. Thus, many pediatric CPD patients may have low IgG, and some may have low IgG1 and IgG2 as a reflection of low total IgG. However, we did not demonstrate a selective absence of IgG2 in these patients.
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Fivush B, Case B, May M, Lederman H (1987) Hypogammaglobulinemia in children undergoing continuous ambulatory peritoneal dialysis. Pediatr Nephrol 3: 186–188
Katz A, Kashtan C, Greenberg L, Shapiro R, Nevins R, Kim Y (1990) Hypogammaglobulinemia in uremic infants receiving peritoneal dialysis. J Pediatr 117: 258–261
Neu AM, Lederman HM, Fivush BA (1993) Hypogammaglobulinemia in infants maintained on CPD. Am J Kidney Dis 22: A7
Schroder C, Bakkeren J, Weemaes C, Monnens L (1989) IgG2 deficiency in young children treated with continuous ambulatory peritoneal dialysis (CAPD). Perit Dial Bull 9: 261–265
Schur PH (1987) IgG subclasses—a review. Ann Allergy 58: 89–96
Harrod H (1993) Clinical significance of IgG subclasses. Curr Opin Pediatr 5: 696–699
Umetsu D, Ambrosino D, Quinti I, Siber G, Geha R (1985) Recurrent sinopulmonary infection and impaired antibody response to bacterial capsular polysaccharide antigen in children with selective IgG-subclass deficiency. N Engl J Med 313: 1247–1251
McIntosh J, Hansen S, Ziegler J, Penny R (1976) Defective immune and phagocytic functions in uraemia and kidney transplantation. Int Arch Allergy Appl Immunol 51: 544–559
Casciani C, De Simone C, Bonini S, Taccone Gallucci M, Matteucci G, Valesini G, Meli D, Masala C (1978) Immunological aspects of chronic uremia. Kidney Int 13: S49-S54
Neu AM, Lederman HM, Fivush BA (1993) Hypogammaglobulinemia and fatal sepsis in an infant maintained on peritoneal dialysis. Pediatr Nephrol 7: 455–456
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Neu, A.M., Case, B.W., Lederman, H.M. et al. IgG subclass levels in pediatric patients on chronic peritoneal dialysis. Pediatr Nephrol 9, 186–188 (1995). https://doi.org/10.1007/BF00860740
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DOI: https://doi.org/10.1007/BF00860740