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Pediatric Nephrology

, Volume 9, Issue 2, pp 176–181 | Cite as

Effects of growth hormone on kidney function in pediatric transplant recipients

  • Blanche M. Chavers
  • Leah Doherty
  • Thomas E. Nevins
  • Marie Cook
  • Kumud Sane
Original Article

Abstract

Recent evidence suggests that treatment with recombinant human growth hormone (rhGH) after a successful kidney transplant improves the growth rate of children with short stature. We prospectively investigated eight children (6 boys, 2 girls), focusing on acute rejection episodes and changes in serum creatinine levels during rhGH treatment. The children (mean age 11.6±3.4 years) received rhGH daily (0.04–0.05 mg/kg subcutaneously). Seven patients completed at least 12 months (20±8 months) of rhGH treatment. Their mean serum creatinine level was 1.3±0.7 mg/dl 12 months before, and increased to 3.4±4.2 mg/dl after 12 months of rhGH treatment, but did not achieve statistical significance (P=0.06). Their mean calculated glomerular filtration rate was 58±20 ml/min per 1.73 m2 12 months before, and decreased to 38±21 ml/min per 1.73 m2 12 months before, and decreased to 38±21 ml/min per 1.73 m2 after 12 months of rhGH treatment, but did not achieve statistical significance (P=0.08). Of the seven patients, two developed acute rejection after 5 and 6 rejection-free years; three lost their grafts and returned to dialysis. These preliminary observations describe untoward renal events in children receiving rhGH treatment after a kidney transplant.

Key words

Recombinant human growth hormone Kidney transplantation Rejection 

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Copyright information

© IPNA 1995

Authors and Affiliations

  • Blanche M. Chavers
    • 1
  • Leah Doherty
    • 1
  • Thomas E. Nevins
    • 1
  • Marie Cook
    • 1
  • Kumud Sane
    • 1
  1. 1.Department of PediatricsUniversity of Minnesota Medical CenterMinneapolisUSA

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