Pediatric Nephrology

, Volume 9, Issue 1, pp 16–18 | Cite as

Absence of hepatitis B and C viruses in pediatric idiopathic membranoproliferative glomerulonephritis

  • Michael J. Nowicki
  • Thomas R. Welch
  • Nafees Ahmad
  • I. Kenneth Kuramoto
  • Eleanor C. Mendoza
  • Jerome B. Zeldis
  • Bahige M. Baroudy
  • William F. Balistreri
Original Article

Abstract

The blood-borne hepatitis viruses, hepatitis B virus (HBV) and hepatitis C virus (HCV), have similar epidemiological features. The association of chronic HBV infection and glomerulonephritis is well established, particularly in children. Recent reports have shown an association between HCV infection and glomerulonephritis in adults. In order to assess the role of these hepatotropic viruses in membranoproliferative glomerulonephritis (MPGN) we screened 34 children with idiopathic MPGN for the presence of HBV and HCV infection using highly sensitive polymerase chain reaction techniques for the detection of HBV DNA and HCV RNA. Also, enzyme-linked immunosorbent assays were used to detect the presence of antibody to hepatitis B surface antigen and antibody to HCV. No evidence of HBV or HCV infection was demonstrated in any of the patients. We conclude that HBV and HCV are not significant causes of idiopathic MPGN in children in the United States.

Key words

Hepatitis B virus Hepatitis C virus Idiopathic membranoproliferative glomerulonephritis 

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Copyright information

© IPNA 1995

Authors and Affiliations

  • Michael J. Nowicki
    • 1
  • Thomas R. Welch
    • 2
  • Nafees Ahmad
    • 3
  • I. Kenneth Kuramoto
    • 4
  • Eleanor C. Mendoza
    • 5
  • Jerome B. Zeldis
    • 5
  • Bahige M. Baroudy
    • 3
  • William F. Balistreri
    • 1
  1. 1.Division of Pediatric Gastroenterology and NutritionChildren's Hospital Research FoundationCincinnatiUSA
  2. 2.Division of Pediatric NephrologyChildren's Hospital Research FoundationCincinnatiUSA
  3. 3.Division of Molecular VirologyJames N. Gamble Institute of Medical ResearchCincinnatiUSA
  4. 4.Center for Blood ResearchSacramento Medical FoundationSacramentoUSA
  5. 5.Department of Internal MedicineUniversity of CaliforniaSacramentoUSA

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