Pediatric Nephrology

, Volume 9, Issue 1, pp 10–10 | Cite as

Ask the expert

  • William M. Bennett

Key words

Grapefruit juice Cyclosporine pharmacokinetics 


  1. 1.
    McMillan MA (1989) Clinical pharmacokinetics of cyclosporine. Pharmacol Ther 42: 135–136PubMedGoogle Scholar
  2. 2.
    Maurer G, Lemaire M (1986) Biotransformation and distribution in blood of cyclosporine and its metabolites. Transplant Proc 18 [Suppl 4]: 25–34PubMedGoogle Scholar
  3. 3.
    Kronbach T, Fischer V, Meyer UA (1988) Cyclosporine metabolism in human liver: identification of a cytochrome P-450III gene family as the major cyclosporine-metabolizing enzyme explains interactions of cyclosporine with other drugs. Clin Pharmacol Ther 43: 630–635PubMedGoogle Scholar
  4. 4.
    Kuhnau J (1990) The flavonoids. A class of semi-essential food components: their role in human nutrition. World Rev Nutr Diet 508: 236–240Google Scholar
  5. 5.
    Miniscalco A, Lundahl J, Regardh CG, Edgar B, Eriksson UG (1992) Inhibition of dihydropyridine metabolism in rat and human liver microsomes by flavonoids found in grapefruit juice. J Clin Pharmacol Exp Ther 261: 1195–1199Google Scholar

Copyright information

© IPNA 1995

Authors and Affiliations

  • William M. Bennett
    • 1
  1. 1.Division of Nephrology, Hypertension and Clinical PharmacologyOregon Health Sciences UniversityPortlandUSA

Personalised recommendations