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Reversible low-molecular-weight proteinuria in patients with distal renal tubular acidosis

Pediatric Nephrology volume 4, pages 593–596 (1990)Cite this article

Abstract

Four patients with untreated renal tubular acidosis had a urinary excretion of low-molecular-weight (LMW) proteins which was restored to normal by alkali therapy. Hypokalaemic proximal tubular damage in untreated patients with distal renal tubular acidosis is believed to be the cause of LMW proteinuria. An examination of urinary excretion of LMW proteins is useful for determining hypokalaemic proximal tubular dysfunction, as well as the efficiency of alkali therapy.

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References

  1. Morris RC, Sebastian A, McSherry E (1972) Renal acidosis, Kidney Int 1: 322–340

    Google Scholar 

  2. Chan JCM (1983) Renal tubular acidosis. J Pediatr 102: 327–340

    Google Scholar 

  3. Noto A, Ogawa Y, Mori S, Yoshioka M, Kitakaze T, Hori T, Nakamura M, Miyake T (1983) Simple, rapid spectrophotometry of urinary N-acetyl-beta-D-glucosaminidase, with use of a new chromogenic substrate. Clin Chem 29: 1713–1716

    Google Scholar 

  4. Ekström B, Berggård I (1977) Human α1-microglobulin. J Biol Chem 252: 8048–8057

    Google Scholar 

  5. Evrin PE, Peterson PA, Bergard I (1971) Radioimmunoassay of beta 2 microglobulin in human biological fluid. J Clin Invest 28: 439–443

    Google Scholar 

  6. Strober W, Waldmann TA (1974) The role of the kidney in the metabolism of plasma proteins. Nephron 13: 35–66

    Google Scholar 

  7. Wibell L, Karlsson FA (1976) The urinary excretion of beta 2 microglobulin after the induction of a diuresis. A study in healthy subjects. Nephron 17: 343–352

    Google Scholar 

  8. Peterson PA, Evrin P-E, Berggård I (1969) Differentiation of glomerular, tubular, and normal proteinuria: determination of urinary excretion of beta 2 microglobulin, albumin, and total protein. J Clin Invest 48: 1189–1198

    Google Scholar 

  9. Hall PW, Vasiljevin M (1973) Beta 2 microglobulin excretion as an index of renal tubular disorders with special reference to endemic Balkan nephropathy. J Lab Clin Med 81: 897–902

    Google Scholar 

  10. Schardijn G, Statius LW, Swaak AJG, Kager JCGM, Persijn JP (1979) Urinary beta 2 microglobulin in upper and lower urinary tract infection. Lancet I: 805–807

    Google Scholar 

  11. Itoh Y, Enomoto H, Kawai T (1983) Alpha 1-microglobulin in cadmium poisoning. Nephron 35: 211–214

    Google Scholar 

  12. Welt LG, Hollander W, Blythe WB (1960) The consequences of potassium depletion. J Chronic Dis 11: 213–254

    Google Scholar 

  13. Antonie B, Patte D, Gourdin MF (1970) Proteins originating in the kidney in the urine of patients with hypokalemia. Am J Clin Pathol 54: 53–59

    Google Scholar 

  14. Harrison JF, Parker RW, Silva KL de (1973) Lysozymuria and acute disorders of renal function. J Clin Pathol 26: 278–284

    Google Scholar 

  15. Schwarz WB, Relman AS (1967) Effects of electrolyte disorders on renal structure and function. N Engl J Med 276: 383–389

    Google Scholar 

  16. Riemenschneider T, Bohle A (1983) Morphologic aspects of low-potassium and low-sodium nephropathy. Clin Nephrol 19: 271–279

    Google Scholar 

  17. Muehrcke RC, Rosen S (1963) Hypokalaemic nephropathy in rat and man: light and electron microscopic study. Lab Invest 13: 1359–1373

    Google Scholar 

  18. Morrison AB, Panner BJ (1964) Lysosome induction in experimental potassium deficiency. Am J Pathol 45: 295–311

    Google Scholar 

  19. Emery C, Young RM, Morgan B, Hay AWM, Tete-Denker D, Rubython J (1984) Tubular damage in patients with hypokalemia. Clin Chim Acta 140: 231–238

    Google Scholar 

  20. Kjellberg J, Piscator M, Castenfors J (1971) Urinary proteins and plasma renin activity during total starvation. Acta Med Scand 190: 519–525

    Google Scholar 

  21. Tolins JP, Hostetter MK, Hostetter TH (1987) Hypokalaemic nephropathy in the rat. J Clin Invest 79: 1447–1458

    Google Scholar 

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Affiliations

  1. Department of Paediatrics, Faculty of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113, Tokyo, Japan

    Takashi Igarashi, Hidehiko Kawato & Shigehiko Kamoshita

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  1. Takashi Igarashi
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  2. Hidehiko Kawato
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  3. Shigehiko Kamoshita
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Igarashi, T., Kawato, H. & Kamoshita, S. Reversible low-molecular-weight proteinuria in patients with distal renal tubular acidosis. Pediatr Nephrol 4, 593–596 (1990). https://doi.org/10.1007/BF00858629

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  • DOI: https://doi.org/10.1007/BF00858629

Key words

  • Alpha1-microglobulin
  • Beta2-microglobulin
  • Distal renal tubular acidosis
  • Hypokalaemia