Pediatric Nephrology

, Volume 4, Issue 1, pp 36–38 | Cite as

Spontaneous remission of nephrotic syndrome in a patient with IgA nephropathy

  • Ronald J. Hogg
  • Daniel A. Savino
Original Article


A patient with spontaneous remission of nephrotic syndrome (NS) associated with IgA nephropathy is described. The patient presented at the age of 8 years with asymptomatic proteinuria, and at the age of 11 years developed classical features of NS. A percutaneous renal biopsy showed mild mesangial prominence without significant hypercellularity, electron-dense deposits within the mesangium, and 3+mesangial staining with IgA and IgG. NS resolved 6 weeks after onset without any form of therapy; absence of protein-uria persisted 6 months later. This report demonstrates clearly that patients with NS associated with IgA nephropathy may undergo spontaneous resolution of their proteinuria.

Key words

Nephrotic syndrome IgA nephropathy 


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  1. 1.
    Berger J (1979) Idiopathic mesangial deposition of IgA. In: Hamburger J, Crosnier J, Grunfeld J-P (eds) Nephrology. Wiley, New York, pp 535–541Google Scholar
  2. 2.
    Saint Andre JP, Simard CL, Spiesser R, Houssin A (1980) Syndrome nephrotique de l'enfant a lesions glomerulaires minimes, avec depots mesangiaux. Nouv Presse Med 9: 531–532Google Scholar
  3. 3.
    Abreo K, Wen S-F (1983) A case of IgA nephropathy with an unusual response to corticosteroid and immunosuppressive therapy. Am J Kidney Dis 3: 54–57PubMedGoogle Scholar
  4. 4.
    Mustonen J, Pasternack A, Rantala I (1983) The nephrotic syndrome in IgA glomerulonephritis: response to corticosteroid therapy. Clin Nephrol 20: 172–176PubMedGoogle Scholar
  5. 5.
    Wu G, Katz A, Cardella C, Oreopoulos DG (1985) Spontaneous remission of nephrotic syndrome in IgA glomerular disease. Am J Kidney Dis 6: 96–99PubMedGoogle Scholar
  6. 6.
    Ida T, Chida Y, Saito F, Tomura S, Shiigai T, Takeuchi J (1984) The patients with massive proteinuria in IgA nephropathy. IXth Int Congr Nephrol 96AGoogle Scholar
  7. 7.
    Yoshikawa Y, Kikuchi H, Tomita T (1984) The nephrotic syndrome in IgA nephritis. IXth Int Congr Nephrol 142AGoogle Scholar
  8. 8.
    Hervé JP, Cledes J, Leroy JP, Simon P, Ramée MP, Legall E (1984) Syndromes nephrotiques cortico-sensibles avec depots mesangiaux d'IgA. 4 observations. Nephrologie 5: 46Google Scholar
  9. 9.
    Hogg RJ, Silva FG (1984) IgA nephropathy: natural history and prognostic indices in children. Contrib Nephrol 40: 214–221 (Discussion pp 238–240)PubMedGoogle Scholar
  10. 10.
    Wyatt RJ, Julian BA, Bhathena DB, Mitchell BL, Holland NH, Malluche HH (1984) IgA nephropathy: presentation, clinical course, and prognosis in children and adults. Am J Kidney Dis 4: 192–200PubMedGoogle Scholar
  11. 11.
    Sinnassamy P, O'Regan S (1985) Mesangial IgA deposits with steroid responsive nephrotic syndrome: probable minimal lesion nephrosis. Am J Kidney Dis 5: 267–269PubMedGoogle Scholar
  12. 12.
    Southwest Pediatric Nephrology Study Group (1985) Association of IgA nephropathy with steroid-responsive nephrotic syndrome. Am J Kidney Dis 5: 157–164Google Scholar
  13. 13.
    Lai KN, Lai FM, Chan KW, Ho CP, Leung ACT, Vallance-Owen J (1986) An overlapping syndrome of IgA nephropathy and lipoid nephrosis. Am J Clin Pathol 86: 716–723PubMedGoogle Scholar
  14. 14.
    Woo KT, Wu A, Lau YK, Lee EJ, Edmondson RP, Pwee HS, Lim CH (1986) Protein selectivity in IgA nephropathy. Nephron 42: 236–239PubMedGoogle Scholar
  15. 15.
    di Belgiojoso GB, Mazzucco G, Casanova S, Radaelli L, Monga G, Minetti L (1986) Steroid-sensitive nephrotic syndrome with mesangial IgA deposits: a separate entiy? Am J Nephrol 6: 141–145PubMedGoogle Scholar
  16. 16.
    Laurent J, Rostoker G, Belghiti D, Lagrue G (1987) A case of adult steroid responsive nephrotic syndrome with IgA deposition; the significance of a concomitant allergic state. Clin Nephrol 28: 49–50PubMedGoogle Scholar
  17. 17.
    Rambausek M, Waldherr R, Rauterberg W, Andrassy K, Ritz E (1987) Mesangial IgA nephropathy and idiopathic nephrotic syndrome. Nephron 47: 190–193PubMedGoogle Scholar
  18. 18.
    Choi Y, Cheong HI, Lee HJ, Lee HS, Kim YI, Ko KW (1987) IgA nephropathy with nephrotic syndrome. Pediatr Nephrol 1: F9–3Google Scholar
  19. 19.
    Henning PH, Binns G, Beare TH, Jureidini KF (1987) Mesangial IgA nephropathy in steroid responsive nephrotic syndrome. Pediatr Nephrol 1: F9–6Google Scholar
  20. 20.
    Hogg RJ, Silva FG (1987) IgA nephropathy in children. In: Clarkson AR (ed) IgA nephropathy. Nijhoff, Dordrecht, pp 16–38Google Scholar
  21. 21.
    Levy M, Gonzalez-Burchard G, Broyer M, Dommergues J-P, Foulard M, Sorez J-P, Habib R (1985) Berger's disease in children: natural history and outcome. Medicine 64: 157–180PubMedGoogle Scholar
  22. 22.
    Hogg RJ (1987) The future: a pediatric perspective. In: Clarkson AR (ed) IgA nephropathy. Nijhoff, Dordrecht, pp 240–254Google Scholar

Copyright information

© IPNA 1990

Authors and Affiliations

  • Ronald J. Hogg
    • 1
  • Daniel A. Savino
    • 2
  1. 1.Department of PediatricsBaylor University Medical CenterDallasUSA
  2. 2.Department of PathologyBaylor University Medical CenterDallasUSA

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