Abstract
It is well known genetic predisposition may play an important role in the pathogenesis of renal diseases. Recently, there has been some controversy about the possible role of the polymorphism of the immunoglobulin heavy chain switch region gene. We have studied this gene bySstI restriction fragment length polymorphisms using DNA from 41 children with IgA nephropathy, 44 with Henoch-Schönlein nephritis and 60 with idiopathic nephrotic syndrome. There was no association of specific genotype with these diseases, in contrast to previous reports. These results are probably due to the differing genetic background of Japanese and Caucasoid patients as far as the switch region is concerned; no switch region genotype constitutes a genetic risk factor for the Japanese in these diseases.
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References
Mills FC, Brooker JS, Camerini-Otero RD (1990) Sequences of human immunoglobulin switch regions: implications for recombination and transcription. Nucleic Acids Res 18: 7305–7316
Migone N, Feder J, Cann H, West B, Hwang J, Takahashi N, Honjo T, Piazza A, Cavalli-Sforza LL (1983) Multiple DNA fragment polymorphisms associated with immunoglobulin m chain-like regions in man. Proc Natl Acad Sci USA 80: 467–471
D'Amico G (1987) The commonest glomerulonephritis in the world: IgA nephropathy. Q J Med 64: 709–727
Levy M, Lesavre P (1992) Genetic factor in IgA nephropathy (Berger's disease) Adv Nephrol 21: 23–51
Demain AG, Rambausek M, Knight JF, Williams PG, Welsh KI, Ritz E (1988) Relation of mesangial IgA glomerulonephritis to polymorphism of immunoglobulin heavy chain switch region. J Clin Invest 81: 611–614
Rambausek M, Waldherr R, Junger E, Krupp G, Demaine A, Ritz E (1989) Immungenetische Untersuchungen bei mesangialer IgA-glomerulonephritis und purpura-Schönlein-Henoch-glomerulonephritis. Verh Dtsch Pathol 73: 124–128
Gross-Bellard M, Outdet P, Chambon P (1973) Isolation of high-molecular-weight DNA from mammalian cells. Eur J Biochem 36: 32–38
Moore RH, Hitman GA, Sinico RA, Mustonen J, Medicraft J, Lucas EY, Richards NT, Venning MC, Cunningham J, Marsh FP, D'Amico G (1990) Immunoglobulin heavy chain switch region gene polymorphisms in glomerulonephritis. Kidney Int 38: 332–336
Ruder H, Sharer K, Opelz G, Leenhard V, Waldherr R, Muller-Wiefel Wingen A, Dippell J (1990) Human leukocyte antigens in idiopathic nephrotic syndrome in children. Pediar Nephrol 4: 478–481
Jin DK, Kohsaka T, Tanaka M, Jun A, Kobayashi N (1991) Human leukocyte antigens in childhood idiopathic nephrotic syndrome. Acta Paediatr Jpn Overseas Ed 33: 709–713
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Jin, D.K., Kohsaka, T. & Kobayashi, N. The polymorphism of the immunoglobulin heavy chain switch region gene in IgA nephropathy, Henoch-Schönlein nephritis and idiopathic nephrotic syndrome. Pediatr Nephrol 7, 449–451 (1993). https://doi.org/10.1007/BF00857569
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DOI: https://doi.org/10.1007/BF00857569