Pediatric Nephrology

, Volume 6, Issue 1, pp 44–45 | Cite as

Normal renal sensitivity to atrial natriuretic peptide in Gordon's syndrome

  • Matti Välimäki
  • Risto Pelkonen
  • Iikka Tikkanen
  • Frej Fyhrquist
Original Article


To test the hypothesis that renal sensitivity to atrial natriuretic peptide (ANP) is impaired in Gordon's syndrome (hypertension and hyperkalaemia with normal glomerular filtration rate) we infused α-hANP into two patients with this syndrome (a sister and a brother, 19 and 18 years of age). For comparison, 11 healthy volunteers were also examined. The infusion of α-hANP increased urinary volume and excretion of sodium similarly in the patients and controls. The excretion of potassium did not change in either the patients or the controls. The infusion of α-hANP had no effect on the serum potassium levels or the plasma CO2 content in the patients. The present results do not confirm the hypothesis of lack of sensitivity to ANP as a pathophysiological concept in Gordon's syndrome.

Key words

Gordon's syndrome Atrial natriuretic hormone Hypertension Hyperkalaemia Acidosis 


  1. 1.
    Gordon RD (1986) Syndrome of hypertension and hyperkalemia with normal glomerular filtration rate. Hypertension 8:93–102PubMedGoogle Scholar
  2. 2.
    Välimäki M, Pelkonen R, Tikkanen I, Fyhrquist F (1989) A deficient response of atrial natriuretic peptide to volume overload in Gordon's syndrome. Acta Endocrinol (Copenh) 120:331–336Google Scholar
  3. 3.
    Semmekrot B, Monnens L, Theelen BGA, Rascher W, Gabreels F, Willems J (1987) The syndrome of hypertension and hyperkalaemia with normal glomerular function (Gordon's syndrome). Pediatr Nephrol 1:473–478PubMedGoogle Scholar
  4. 4.
    Hynynen M, Kupari M, Salmenperä M, Tikkanen I, Heinonen J, Fyhrquist F, Tötterman KJ (1988) Hemodynamic effects of α-human atrial natriuretic peptide in healthy volunteers. J Cardiovasc Pharmacol 11:711–715PubMedGoogle Scholar
  5. 5.
    Tikkanen I, Fyhrquist F, Metsärinne K, Leidenius R (1985) Plasma atrial natriuretic peptide in cardiac disease and during infusion in healthy volunteers. Lancet II:66–69Google Scholar
  6. 6.
    Tunny TJ, Higgins BA, Gordon RD (1986) Plasma levels of atrial natriuretic peptide in man in primary aldosteronism, in Gordon's syndrome and in Bartter's syndrome. Clin Exp Pharmacol Physiol 13: 341–345PubMedGoogle Scholar

Copyright information

© IPNA 1992

Authors and Affiliations

  • Matti Välimäki
    • 1
  • Risto Pelkonen
    • 1
  • Iikka Tikkanen
    • 2
  • Frej Fyhrquist
    • 2
  1. 1.Third Department of MedicineUniversity Central Hospital of HelsinkiHelsinkiFinland
  2. 2.Fourth Department of MedicineUniversity Central Hospital of HelsinkiHelsinkiFinland

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