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Pediatric Nephrology

, Volume 6, Issue 1, pp 44–45 | Cite as

Normal renal sensitivity to atrial natriuretic peptide in Gordon's syndrome

  • Matti Välimäki
  • Risto Pelkonen
  • Iikka Tikkanen
  • Frej Fyhrquist
Original Article

Abstract

To test the hypothesis that renal sensitivity to atrial natriuretic peptide (ANP) is impaired in Gordon's syndrome (hypertension and hyperkalaemia with normal glomerular filtration rate) we infused α-hANP into two patients with this syndrome (a sister and a brother, 19 and 18 years of age). For comparison, 11 healthy volunteers were also examined. The infusion of α-hANP increased urinary volume and excretion of sodium similarly in the patients and controls. The excretion of potassium did not change in either the patients or the controls. The infusion of α-hANP had no effect on the serum potassium levels or the plasma CO2 content in the patients. The present results do not confirm the hypothesis of lack of sensitivity to ANP as a pathophysiological concept in Gordon's syndrome.

Key words

Gordon's syndrome Atrial natriuretic hormone Hypertension Hyperkalaemia Acidosis 

References

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Copyright information

© IPNA 1992

Authors and Affiliations

  • Matti Välimäki
    • 1
  • Risto Pelkonen
    • 1
  • Iikka Tikkanen
    • 2
  • Frej Fyhrquist
    • 2
  1. 1.Third Department of MedicineUniversity Central Hospital of HelsinkiHelsinkiFinland
  2. 2.Fourth Department of MedicineUniversity Central Hospital of HelsinkiHelsinkiFinland

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