Abstract
We studied the plasma renin activity (PRA) and blood pressure (BP) responses to a single oral dose of captopril in children with renal scarring due to vesicoureteral reflux. The test was performed on 19 children, of whom 13 were normotensive and 6 hypertensive. Basal PRA was within the normal range for age for all except 1 patient. Mean basal PRA values for normotensive and hypertensive patients were not significantly different. At 90 min post captopril, the mean PRA increase was 3.61 ng/l per second (SD=7.07) in the normotensive group but only 0.77 ng/l per second (SD=0.83) in the hypertensive group. In 11 patients the average systolic BP 60–90 min post captopril was 0.9%–12.4% lower than the basal value. Diastolic BP decreased after captopril administration in 10 patients and increased in 9. The changes in mean arterial pressure and PRA between 0 and 90 min post captopril were inversely correlated (r=0.605,P<0.01). Because of the PRA responsiveness in the normotensive patients with renal scarring, we suggest that there was activation of the renin-angiotensin axis in this group. However, it is not apparent whether such patients are more at risk of developing hypertension at a later time.
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Hamed, R.M.A., Ellis, G., Levy, M. et al. Captopril test in children with reflux nephropathy. Pediatr Nephrol 6, 33–37 (1992). https://doi.org/10.1007/BF00856826
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DOI: https://doi.org/10.1007/BF00856826