Journal of Neurology

, Volume 239, Issue 8, pp 426–430 | Cite as

Ubiquitin-positive intraneuronal inclusions in the extramotor cortices of presenile dementia patients with motor neuron disease

  • Koichi Okamoto
  • Nobuyuki Murakami
  • Hirofumi Kusaka
  • Mari Yoshida
  • Yoshio Hashizume
  • Yoichi Nakazato
  • Etsuro Matsubara
  • Shunsaku Hirai
Original Communications


Ubiquitin-positive intraneuronal inclusions were found in the extramotor cortices of ten presenile dementia patients with motor neuron disease. There were inclusions in the hippocampal granular cells and in the small neurons of the superficial layers of the temporal and frontal cortices. Bunina bodies were present in the anterior horn cells in all cases. These results suggest that ubiquitin-related cytoskeletal abnormalities are common in cerebral non-motor small neurons in these patients.

Key words

Motor neuron disease Dementia Ubiquitin Amyotrophic lateral sclerosis 


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Copyright information

© Springer-Verlag 1992

Authors and Affiliations

  • Koichi Okamoto
    • 1
  • Nobuyuki Murakami
    • 3
  • Hirofumi Kusaka
    • 4
  • Mari Yoshida
    • 3
  • Yoshio Hashizume
    • 5
  • Yoichi Nakazato
    • 2
  • Etsuro Matsubara
    • 2
  • Shunsaku Hirai
    • 1
  1. 1.Department of NeurologyGunma University School of MedicineGunmaJapan
  2. 2.Department of PathologyGunma University School of MedicineGunmaJapan
  3. 3.Department of NeurologyHigashi Nagoya National HospitalNagoyaJapan
  4. 4.Department of NeurologyKitano HospitalOsakaJapan
  5. 5.Department of PathologyNagoya University School of MedicineNagoyaJapan

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