Pediatric Nephrology

, Volume 8, Issue 4, pp 480–482 | Cite as

Alternate-day steroids affect carpal maturation more than radius, ulna and short bones

  • Cesare Polito
  • Nicola Greco
  • Antonio Opallo
  • Ersilia Cimmaruta
  • Angela La Manna
Brief Report


Radius, ulna, short bones (RUS) and carpal (CARP) bone age were assessed in 26 steroid-dependent nephrotic boys after at least 1 year of alternate-day prednisone therapy, and in 26 age-and sex-matched control subjects. No significant difference in RUS bone age was found between patients and controls. CARP bone age of patients was significantly (P=0.01) more retarded than in controls. In patients, CARP bone age delay was related to their relative height at the time of study (P=0.01). We conclude that CARP bones are more prone to effects of steroids than are RUS bones. Therefore, CARP bone age may be a more sensitive tool in monitoring the effects of steroids on skeletal growth and maturation.

Key words

Skeletal maturity Steroids Nephrotic syndrome 


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Copyright information

© IPNA 1994

Authors and Affiliations

  • Cesare Polito
    • 1
  • Nicola Greco
    • 2
  • Antonio Opallo
    • 1
  • Ersilia Cimmaruta
    • 1
  • Angela La Manna
    • 1
  1. 1.Department of Paediatrics, 3rd Paediatric ClinicSecond University of NaplesNaplesItaly
  2. 2.Radiological Sciences InstiteSecond University of NaplesNaplesItaly

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