Abstract
We evaluated the clinicopathological features and the outcome of 33 children with primary glomerulonephritis (GN) as the cause of renal failure; 17 had asymptomatic (ASP) haematuria and/or proteinuria and the remaining 16 had symptoms suggestive of GN. The renal histology in the ASP group indicated IgA GN in 6 children, focal segmental glomerular sclerosis (FSGS) in 4, diffuse proliferative GN (DPGN) in 3, membranous GN (MGN) in 1, membranoproliferative GN (MPGN) in 1 and diffuse sclerosing GN in 2. In the symptomatic (SYP) group, FSGS was evident in 9 children, DPGN in 3, MGN in 2, IgA GN in 1 and MPGN in 1. There was no difference in the histological severity between the two groups. Fourteen children in the SYP group had nephrotic syndrome (NS) and/or hypertension at their initial visits. Only 4 children in the ASP group showed NS or hypertension during the period of follow-up. Eleven children in the ASP group and all in the SYP group were treated with immunosuppressive and/or antihypertensive drugs, but these did not improve the prognosis of the ASP children compared with those in the SYP group. There was no significant difference in the mean duration between the onset of the disease and the start of dialysis in these two groups. In conclusion, it is questionable whether the urinary mass screening programme in Japan will alter the outcome of children with GN.
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References
Kitagawa T (1988) Lessons learned from the Japanese nephritis screening study. Pediatr Nephrol 2: 256–263
Hisano S, Ueda K (1989) Asymptomatic haematuria and proteinuria: renal pathology and clinical outcome in 54 children. Pediatr Nephrol 3: 229–234
Hisano S, Kawano M, Hatae K, Kaku Y, Yamane I, Ueda K, Uragoh K Honda S (1991) Asymptomatic isolated microhaematuria: natural history of 136 children. Pediatr Nephrol 5: 578–581
Hisano S, Kawano M, Kaku Y, Yamane I, Hatae K, Uragoh K, Matsuzaki A, Ueda K (1991) The natural history of screening detected IgA glomerulonephritis in children. Acta Paediatr Scand 80: 1044–1050
Hisano S, Tsuru N, Hattori S, Uchiyama M, Tamanaha K, Ninomiya M, Furuse A, Yamagishi M, Hohjoh M, Nagano K, Hashiguchi K, Yanase T, Ohbu K, Mukuno K, Kuriya N, Yamashita F (1990) Epidemiologic survey of children with end-stage renal disease. Acta Paediatr Jpn 32: 343–348
Hisano S, Tsuru N (1990) Epidemiologic survey in children with end-stage renal disease: a report of Kyushu Pediatric Nephrology Study Group (abstract). Pediatr Nephrol 4: C79
Hisano S, Tsuru N (1992) Chance hematuria and/or proteinuria: an epidemiologic study of 34 children with end-stage renal disease (abstract). Pediatr Nephrol 6: C12
Task Force on Blood Pressure Control in Children (1987) Report of the second task force on blood pressure control in children. Pediatrics 79: 1–25
Sakaguchi H (1979) World Health Organization classification of glomerular disease. Jpn J Nephrol 21: 349–355
Yoshikawa N, Itoh H, Akamatsu R, Matsuyama S, Hasegawa O, Nakahara C, Matsuo T (1986) Focal segmental glomerulosclerosis with and without nephrotic syndrome in children. J Pediatr 109: 65–70
Ito K (1988) Present status in children in Japan (in Japanese) Shouni Jinfuzen Kenkyukaishi 8: 253–257
Kirks DR (1984) Imaging of the pediatric urinary tract. In: Tune BM, Mendoza SA, Brenner BM (eds) Pediatric nephrology. Churchill Livingstone, New York, pp 21–60
Fine RN (1985) The adolescent with end-stage renal disease. Am J Kidney Dis 6: 81–85
Southwest Pediatric Nephrology Study Group (1985) Continuous ambulatory and cycling peritoneal dialysis in children. A report of the Southwest Pediatric Nephrology Study Group. Kidney Int 27: 558–564
Hanna JD, Foreman JW, Chan JCM (1991) Chronic renal insufficiency in infants and children. Clin Pediatr (Phila) 30: 365–384
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Further participating centres: Oita Medical School, Oita, Japan (Makoto Uchiyama); Okinawa Prefectural Chubu Hospital, Naha, Japan (Koichiroh Tamanaha); Kagoshima University, Kagoshima, Japan (Makoto Ninomiya); Nishibeppu National Hospital, Beppu, Japan (Akio Furuse); School of Medicine, University of Occupational and Environmental Health, Kitakyushu, Japan (Minoru Yamagishi); Saga Medical School, Saga, Japan (Tadashi Satoh); Nagasaki University, Nagasaki, Japan (Kiyoaki Nagano); Miyazaki Medical School, Miyazaki, Japan (Kanehide Hashiguchi); Fukuoka Red Cross Hospital, Fukuoka, Japan (Tetsuro Yanase); Yahata Saiseikai Hospital, Kitakyushu, Japan (Keizo Ohbu); Kokura National Hospital, Kitakyushu, Japan (Kumiko Mukuno)
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Hisano, S., Tsuru, N., Itoh, Y. et al. Comparison of asymptomatic and symptomatic childhood glomerulonephritis progressing to renal failure: a report of Kyushu Pediatric Nephrology Study Group. Pediatr Nephrol 8, 423–426 (1994). https://doi.org/10.1007/BF00856520
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DOI: https://doi.org/10.1007/BF00856520