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Catalytic preparation of ketones of the pyridine series

  • V. I. Yakerson
  • L. I. Lafer
  • A. M. Rubinshtein
Organic and Biological Chemistry

Conclusions

  1. 1.

    A vapor-phase catalytic method is proposed for the preparation of difficultly accessible pyridine ketones over a ZrO2 or 15 mol.% ZrO2-Al2O3 catalyst, which has very good stability.

     
  2. 2.

    With increase in the molecular weight of the fatty acid the yield of ketone falls, and the yield of pyridine rises.

     
  3. 3.

    By the catalytic coketonization of ethyl nicotinate and isonicotinate with acetic, propionic, butyric, and valeric acids at a molar ratio of 1 ∶ 4 at 450–460°, 3- and 4-acetyl-, 3- and 4-propionyl-, 3- and 4-butyryl-, and 3- and 4-valerylpyridines were isolated in good yields.

     

Keywords

Acetic Molecular Weight Ethyl Nicotinate Pyridine 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Consultants Bureau 1966

Authors and Affiliations

  • V. I. Yakerson
    • 1
  • L. I. Lafer
    • 1
  • A. M. Rubinshtein
    • 1
  1. 1.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRUSSR

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