Advertisement

Relation between spatial structure and central N-cholinolytic action in the 1,2,4-substituted decahydroquinoline series

  • B. B. Kuz'mitskii
  • A. A. Akhrem
  • L. I. Ukhova
  • N. F. Uskova
Organic and Biological Chemistry
  • 17 Downloads

Conclusions

  1. 1.

    A study was made of the central cholinolytic activity and toxicity of some 1,2,4-substituted decahydroquinolines.

     
  2. 2.

    The studied decahydroquinoline derivatives exhibit central N-cholinolytic (antinicotinic) action.

     
  3. 3.

    It was established that a definite relationship exists between the chemical structure, the conformation and the N-cholinolytic action in the series of 1,2,4-substituted decahydroquinolines.

     

Keywords

Toxicity Spatial Structure Definite Relationship Decahydroquinoline 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Literature cited

  1. 1.
    A. A. Akhrem, B, B, Kuz'mitskii, L. I. Ukhova, and N. F. Uskova, Dokl. Akad. Nauk SSSR,169, No. 3, 724 (1966).PubMedGoogle Scholar
  2. 2.
    V. I. Zaretskii, N. S. Vul'fson, V. G. Zaikin, A. A. Akhrem, L. I. Ukhova, and N. F. Uskova, Izv. Akad. Nauk SSSR, Ser. Khim., 2164 (1968).Google Scholar
  3. 3.
    A. A. Akhrem, L. I. Ukhova, and N. F. Uskova, Izv. Akad. Nauk SSSR, Otd. Khim. Nauk, 304 (1962).Google Scholar
  4. 4.
    A. A. Akhrem, L. I. Ukhova, and N. F. Uskova, Izv. Akad. Nauk SSSR, Ser. Khim., 900 (1970).Google Scholar
  5. 5.
    A. A. Akhrem, L. I. Ukhova, and N. F. Uskova, Izv. Akad. Nauk SSSR, Ser. Khim., 2305 (1970).Google Scholar
  6. 6.
    I. V. Golyakhovskii, Farmakol. i Toksikol.,11, 8 (1948).Google Scholar
  7. 7.
    M. V. Pan'shina, Farmakol. i Toksikol.,14, 45 (1951).Google Scholar
  8. 8.
    D. Bovet and V. G. Longo, J. Pharmacol. Exptl. Therap.,102, 22 (1951).Google Scholar
  9. 9.
    R. L. Cahen and T. E. Lynes, J. Pharmacol, and Exptl. Therap.,103, 44 (1951).Google Scholar
  10. 10.
    M. D. Mashkovskii, Farmakol. i. Toksikol.,16, 3 (1953).Google Scholar
  11. 11.
    M. Ya. Mikhel'son and Ya. R. Savinskii, Farmakol. i Toksikol.,16, 57 (1953).Google Scholar
  12. 12.
    E. V. Zeimal, Byul. Éksperim. Biol. i Med.,39, 42 (1955).Google Scholar
  13. 13.
    S. N. Golikov, Farmakol. i Toksikol.,19, 38 (1956).Google Scholar
  14. 14.
    S. S. Liberman, Farmakol. i Toksikol.,19, 10 (1956).Google Scholar
  15. 15.
    E. V. Zeimal and R. S. Rybalovlev in: Physiological Role of Acetylcholine and Search for New Drugs, M. Ya. Mikhel'son (editor) [in Russian], Medgiz, Leningrad (1957), p.338.Google Scholar
  16. 16.
    N. A. Kharauzov, in: Selective Action of Drugs on the Central Nervous System, S. V. Anichkov (editor) [in Russian], Medgiz, Leningrad (1958), p. 104.Google Scholar
  17. 17.
    B. Blum and S. Zacks, J. Pharmacol. Exptl. Therap.,124, 350 (1958).Google Scholar
  18. 18.
    I. Yamamoto, K. Otori, and R. Inoki, Japan. J. Pharmacol.,16, 402 (1966).Google Scholar
  19. 19.
    J. T. Litchfield and F. Wilcoxon, J. Pharmacol. Exptl. Therap.,96, 99 (1944).Google Scholar
  20. 20.
    M. L. Belen'kii, Elements for the Quantitative Estimate of the Pharmacological Effect [in Russian], Medgiz, Leningrad (1963).Google Scholar

Copyright information

© Consultants Bureau 1971

Authors and Affiliations

  • B. B. Kuz'mitskii
    • 1
    • 2
  • A. A. Akhrem
    • 1
    • 2
  • L. I. Ukhova
    • 1
    • 2
  • N. F. Uskova
    • 1
    • 2
  1. 1.Minsk Medical Institute, Institute of Physical-Organic ChemistryAcademy of Sciences of the Belorussian SSRUSSR
  2. 2.N. D. Zelinskii Institute of Organic ChemistryAcademy of Sciences of the USSRUSSR

Personalised recommendations