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Amino acids as C-H acids

Communication 1. Synthesis of glutamic acid from glycine and methyl acrylate

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    Under the influence of bases, copper salicylideneglycinate adds to an activated C=C double bond, which is a reaction that is typical for C-H acids.

  2. 2.

    Besides salicylaldehyde, acetaldehyde forms a Schiff base with glycine that is quite active in the given reaction.

  3. 3.

    A new method was proposed for the synthesis of glutamic acid from glycine and methyl acrylate.

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Authors and Affiliations

  1. Institute of Heteroorganic Compounds, Academy of Sciences of the USSR, USSR

    Yu. N. Belokon', V. M. Belikov, N. I. Kuznetsova & M. M. Dolgaya

Authors
  1. Yu. N. Belokon'
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  2. V. M. Belikov
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  3. N. I. Kuznetsova
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  4. M. M. Dolgaya
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 6, pp. 1338–1341, June, 1972.

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Belokon', Y.N., Belikov, V.M., Kuznetsova, N.I. et al. Amino acids as C-H acids. Russ Chem Bull 21, 1288–1291 (1972). https://doi.org/10.1007/BF00854546

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  • DOI: https://doi.org/10.1007/BF00854546

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