Conclusions
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1.
A new one-step method was developed for the synthesis of 3′(2′)-O-aminoacylnucleotides by the reaction of protonated amino acids with nucleoside 5′-phosphates in the presence of N,N-carbonyldiimidazole.
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2.
It was shown that racemization is absent during the formation of the imidazolides of N-protonated amino acids and the condensation of the latter with nucleotides in aqueous medium.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2529–2535, November, 1971.
The authors express their deep gratitude to V. I. Ivanov for taking the circular dichroism spectra and participating in a discussion of the results.
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Gottikh, B.P., Kraevskii, A.A. & Purygin, P.P. Aminoacyl derivatives of nucleosides, nucleotides, and polynucleotides Communication 12. Synthesis of 3′(2′)-O-L-aminoacylnucleotides without prior protection of the amino group. Russ Chem Bull 20, 2396–2401 (1971). https://doi.org/10.1007/BF00854321
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DOI: https://doi.org/10.1007/BF00854321