Conclusions
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1.
A method was developed for the preparation of the esters of N-acylaminomethylphosphonic acids by the reaction of the N-dialkylaminomethylamides of monobasic acids with trialkyl phosphites.
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2.
The reaction of N-dimethylaminomethylphthalimide with trialkyl phosphites in the presence of a salt-forming agent, which has a labile hydrogen atom, proceeds with the formation of the esters of dimethyl-aminomethylphosphonic acid. Salt-forming agents of the alkyl halide type lead to the formation of the ester of N-phthalimidomethylphosphonic acid.
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Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 11, pp. 2493–2499, November, 1971.
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Ivanov, B.E., Krokhina, S.S. Reaction of N-aminomethylamides of carboxylic acids with phosphorous acid esters. Russ Chem Bull 20, 2364–2368 (1971). https://doi.org/10.1007/BF00854314
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DOI: https://doi.org/10.1007/BF00854314