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Derivatives of phosphorus acids and α-chloroallyl alcohol

Communication 2. Synthesis of mixed α-chloroallyl esters of phosphoric acid and some of their biological properties

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Bulletin of the Academy of Sciences of the USSR, Division of chemical science Aims and scope

Conclusions

  1. 1.

    A series of derivatives of phosphorus acids andα-chloroallyl alcohol was obtained.

  2. 2.

    Increasing the length of the hydrocarbon radical attached to the phosphorus atom from C1 to C6 leads to a sharp increase in the selectivity of the action of the compounds towardTrichophyton gypseum andEpidermophyton Kaufmann-Wolf. A further increase in the length of the radical decreases the anti-fungal activity of the compounds.

  3. 3.

    It was established that di-n-amylα-chloroallyl phosphate has the highest selectivity index of action toward dermatophytes.

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Literature cited

  1. B. A. Arbuzov, V. M. Zoroastrova, N. D. Ibragimova, I. D. Neklesova, B. L. Mazur, M. A. Kudrina, N. V. Egorova, and I. S. Iraidova, Izv. Akad. Nauk SSSR, Ser. Khim., 1278 (1967).

  2. M. L. Belen'kii, Elements of Quantitative Evaluation of the Pharmacological Effect [in Russian], Medgiz, Leningrad (1963).

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Authors and Affiliations

  1. A. M. Butlerov Chemical Institute of the V. I. Ul'yanov-Lenin Kazan State University, USSR

    B. A. Arbuzov, V. M. Zoroastrova, I. D. Neklesova, M. A. Kudrina, N. V. Egorova & G. A. Tudrii

  2. A. E. Arbuzov Institute of Organic and Physical Chemistry, Academy of Sciences of the USSR, USSR

    B. A. Arbuzov, V. M. Zoroastrova, I. D. Neklesova, M. A. Kudrina, N. V. Egorova & G. A. Tudrii

Authors
  1. B. A. Arbuzov
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  2. V. M. Zoroastrova
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  3. I. D. Neklesova
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  4. M. A. Kudrina
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  5. N. V. Egorova
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  6. G. A. Tudrii
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Additional information

Translated from Izvestiya Akademii Nauk SSSR, Seriya Khimicheskaya, No. 5, pp. 1155–1159, May, 1972.

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Arbuzov, B.A., Zoroastrova, V.M., Neklesova, I.D. et al. Derivatives of phosphorus acids and α-chloroallyl alcohol. Russ Chem Bull 21, 1106–1108 (1972). https://doi.org/10.1007/BF00853779

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  • DOI: https://doi.org/10.1007/BF00853779

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