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Regulation of renal phosphate reabsorption: concepts in evolution

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References

  1. Knox FG, Haramati A (1985) Renal regulation of phosphate excretion. 59 In: Seldin DW, Giebisch G (eds) The kidney: physiology and pathophysiology. Raven Press, New York, Vol 2, p 1381

    Google Scholar 

  2. Harris CA, Baer PG, Chirito E, Dirks JH (1974) Composition of mammalian glomerular filtrate. Am J Physiol 227: 972–976

    PubMed  Google Scholar 

  3. Agus ZS, Puschett JB, Senesky D, Goldberg M (1971) Mode of action of parathyroid hormone and cyclic adenosine 3′–5′-monophosphate on renal tubular phosphate reabsorption in the dog. J Clin Invest 50: 617–626

    PubMed  Google Scholar 

  4. Baumann K, de Roouffignac C, Roinel N, Rumrich G, Ullrich KJ (1975) Renal phosphate transport: inhomogeneity of local proximal transport rates and sodium dependence. Pflügers Arch 356: 287–297

    Google Scholar 

  5. Amiel C, Kuntziger HE, Richet G (1970) Micropuncture study of handling of phosphate by proximal and distal nephron in normal and parathyoidectomized rat. Evidence for distal reabsorption. Pflügers Arch 317: 92–109

    Google Scholar 

  6. Lang F, Greger R, Marchand GR, Knox FG (1977) Stationary microperfusion study of phosphate reabsorption in proximal and distal nephron segments. Pflügers Arch 368: 45–48

    Google Scholar 

  7. Rocha AS, Magaldi JB, Kokko JP (1977) Calcium and phosphate transport in isolated segments of rabbit's Henle's loop. J Clin Invest 59: 975–984

    PubMed  Google Scholar 

  8. Brunette MG, Taleb L, Carriere S (1973) Effect of parathyroid hormone on phosphate reabsorption along the nephron of the rat. Am J Physiol 225: 1076–1081

    PubMed  Google Scholar 

  9. Haramati A, Knox FG (1981) Is phosphate reabsorbed by the distal nephron? Min Elect Metab 6: 165–173

    Google Scholar 

  10. Haas JA, Berndt TJ, Knox F (1978) Nephron heterogeneity of phosphate reabsorption. Am J Physiol 234: F287-F300

    PubMed  Google Scholar 

  11. Poujeol P, Jamison RL, de Rouffignac C (1980) Phosphate reabsorption in juxtamedullary nephron terminal segments. Pflügers Arch 387: 27–31

    Google Scholar 

  12. Haramati A, Haas JA, Knox FG (1983) Adaptation of deep and superficial nephrons to changes in dietary phosphate intake. Am J Physiol 246: F155-F158

    Google Scholar 

  13. Pastoria-Munoz E, Mishler DR, Lechene C (1983) Effect of phosphate deprivation on phosphate reabsorption in rat nephron: Role of PTH. Am J Physiol 244: F140-F149

    PubMed  Google Scholar 

  14. Dennis VW, Woodhall PB, Robinson RR (1976) Characteristics of phosphate transport in isolated proximal tubule. Am J Physiol 231: 979–985

    PubMed  Google Scholar 

  15. Hoffman N, Thees M, Kinne R (1976) Phosphate transport by isolated renal brush border vesicles. Pflügers Arch 362: 147–156

    Google Scholar 

  16. Ullrich KJ, Murer H (1982) Sulfate and phosphate transport in rat kidney proximal tubule. Philos Trans R Soc Lond B Biol Sci 299: 549–558

    PubMed  Google Scholar 

  17. Cheng L, Sacktor B (1981) Sodium gradient-dependent phosphate transport in renal brush border membrane vesicles. J Biol Chem 256: 1556–1564

    PubMed  Google Scholar 

  18. Hammerman MR, Karl IE, Hruska KA (1980) Regulation of canine renal vesicle Pi transport by growth hormone and parathyroid hormone. Biochim Biophys Acta 603: 322–335

    PubMed  Google Scholar 

  19. Burckhardt G, Stern H, Murer H (1981) The influence of pH on phosphate transport into rat renal brush border membrane vesicles. Pflügers Arch 390: 191–197

    Google Scholar 

  20. Samarzija I, Molnar V, Froemter E (1983) pH-dependence of phosphate absorption in rat renal proximal tubule. Proc Eur Dial Transplant Assoc 19: 779–783

    PubMed  Google Scholar 

  21. Freeman D, Bartlett S, Radda G, Ross B (1983) Energetics of sodium transport in the kidney. Saturation transfer31P-NMR. Biochim Biophys Acta 762: 325–336

    PubMed  Google Scholar 

  22. Gmaj P, Murer H (1986) Cellular mechanisms of inorganic phosphate transport in kidney. Physiol Rev 66: 36–70

    PubMed  Google Scholar 

  23. Brunette MG, Chan M, Maag V, Beliveau R (1984) Phosphate uptake by superficial and deep nephron brush border membranes. Effect of dietary phosphate and parathyroid hormone. Pflügers Arch 400: 356–362

    Google Scholar 

  24. Walker JJ, Yan TS, Quamme GA (1987) Presence of multiple sodium-dependent phosphate transport processe in proximal brush-border membranes. Am J Physiol 252: F226-F231

    PubMed  Google Scholar 

  25. Ullrich KJ, Rumrich G, Kloss S (1977) Phosphate transport in the proximal convolution of the rat kidney. I. Tubular heterogeneity, effect of parathyroid hormone in acute and chronic parathyroidectomized animals and effect of phosphate diet. Pflügers Arch 372: 269–274

    Google Scholar 

  26. Brazy PC, Dennis VW (1981) Sulfate transport in rabbit proximal convoluted tubules: presence of anion exchange. Am J Physiol 241 (Renal Fluid Electrolyte Physiol 10): F300–307

    PubMed  Google Scholar 

  27. Schwab SJ, Klahr S, Hammerman MR (1984) Na+ gradient-dependent Pi uptake in basolateral membrane vesicles from dog kidney. Am J Physiol 246 (Renal Fluid Electrolyte Physiol 15): F663-F669

    PubMed  Google Scholar 

  28. Hammerman MR, Schwab SJ (1984) Phosphate transport in the kidney. Studies with isolated membrane vesicles. In: Bronner F, Peterlik M (eds) Epithelial calcium and phosphate transport: molecular and cellular aspects. Liss, New York, p 325–330

    Google Scholar 

  29. Amstutz M, Mohrmann M, Gmaj P, Murer H (1985) The effect of pH on phosphate transport in rat renal brush border membrane vesicles. Am J Physiol 248 (Renal Fluid Electrolyte Physiol 17): F705-F710

    PubMed  Google Scholar 

  30. Murer H, Burckhardt G (1983) Membrane transport of anions across epithelia of mammalian small intestine and kidney proximal tubule. Rev Physiol Biochem Pharmacol 96: 1–53

    PubMed  Google Scholar 

  31. Sacktor B, Cheng L (1981) Sodium gradient-dependent phosphate transport in renal brush border membrane vesicles. Effect of an intravesicular greater than extravesicular proton gradient. J Biol Chem 256: 8080–8084

    PubMed  Google Scholar 

  32. Biber J, Malmstroem K, Scalera V, Murer H (1983) Phosphorylation of rat kidney proximal tubular brush border membranes. Role of cAMP-dependent protein phosphorylation in the regulation of phosphate transport. Pflügers Arch 398: 221–226

    Google Scholar 

  33. Hammerman MR, Cohn DE, Tamayo J, Martin KJ (1983) Effect of parathyroid hormone on Na+-dependent phosphate transport and cAMP-dependent32P phosphorylation in brush border vesicles from isolated perfused canine kidneys. Arch Biochem Biophys 227: 91–97

    PubMed  Google Scholar 

  34. Hammerman MR, Hruska KA (1982) Cyclic AMP-dependent protein phosphorylation in canine renal brush border membrane vesicles is associated with decreased phosphate transport. J Biol Chem 257: 992–999

    PubMed  Google Scholar 

  35. Hammerman MR, Schwab SJ (1984) Phosphate transport in the kidney. Studies with isolated membrane vesicles. In: Bronner F, Peterlik M (eds) Epithelial calcium and phosphate transport: molecular and cellular aspects. Liss, New York, pp 325–330

    Google Scholar 

  36. Malmstrom K, Biber J, Gmaj P, Murer H (1984) Possible mechanisms for the regulation of the Pi transport in brush border membrane vesicles. In: Bronner F, Peterlik M (eds) Epithelial calcium and phosphate transport: molecular and cellular aspects. Liss, New York, pp 331–336

    Google Scholar 

  37. George ER, Balakir RA, Filburn CR, Sacktor B (1977) Cyclic adenosine monophosphate dependent and independent protein kinase activity of renal brush border membranes. Arch Biochem Biophys 180: 429–443

    PubMed  Google Scholar 

  38. Hammerman MR (1986) Phosphorylation of type II cAMP-dependent protein kinase in renal brush border membranes. Am J Physiol 250: F659-F666

    PubMed  Google Scholar 

  39. Bellorin-Font E, Martin KJ (1981) Regulation of the PTH-receptor-cyclase system of canine kidney: effects of calcium, magnesium, and guanine nucleotides. Am J Physiol 241: F364-F373

    PubMed  Google Scholar 

  40. Wright BS, Tyler GA, O'Brien R, Caproale LH, Rosenblatt M (1987) Immunoprecipitation of the parathyroid hormone receptor. Proc Natl Acad Sci USA 84: 26–30

    PubMed  Google Scholar 

  41. Gilman AG (1984) G proteins and dual control of adenylate cyclase. Cell 36: 577–579

    PubMed  Google Scholar 

  42. Stryer L (1986) Cyclic GMP cascade of vision. Annu Rev Neurosci 9: 87–119

    PubMed  Google Scholar 

  43. Agus ZS, Gardner LB, Beck LH, Goldberg M (1973) Effects of parathyroid hormone on renal tubular reabsorption of calcium, sodium, and phosphate. Am J Physiol 224: 1143–1148

    PubMed  Google Scholar 

  44. Kurokawa K, Ohno T, Rasmussen H (1973) Ionic control of renal gluconeogenesis. II. The effects of Ca2+ and H+ upon the response to parathyroid hormone and cyclic AMP. Biochim Biophys Acta 313: 32–41

    PubMed  Google Scholar 

  45. Lau K, Goldfarb S, Goldberg M (1980) The effects of parathyroid hormone on renal phosphate handling. In: Massry SG, Fleisch H (eds) Renal handling of phosphate. Plenum Press, New York, pp 115–135

    Google Scholar 

  46. Rasmussen H, Goodman DBP, Friedmann N, Allen JE, Kurokawa K (1976) Ionic control of metabolism. In: Greep RO, Astwood EB (eds) Handbook of physiology, endocrinology. Am Physiol Soc, Washington DC, vol VII, pp 225–264

    Google Scholar 

  47. Flockhart DA, Corbin JD (1982) Regulatory mechanisms in the control of protein kinases. In: Fasman GD (ed) Critical reviews in biochemistry. CRC Press, Boca Raton, FL, vol 12, p 133–186

    Google Scholar 

  48. Malstrom K, Murer H (1987) Intracellular cascades in PTH-dependent regulation of Na/phosphate cotransport in OK cells. In: Fiskum G (ed) Cell calcium metabolism, Washington DC, Seventh international Washington spring symposium 248A

  49. Chambers DJ, Dunham J, Zanelli JM, Parsons JA, Bitensky L, Chayer J (1978) A sensitive bioassay of parathyroid hormone in plasma. Clin Endocrinol 9: 375–379

    Google Scholar 

  50. Teitelbaum AP, Strewler GJ (1984) Parathyroid hormone receptors coupled to cyclic adenosine monophosphate formation in an established renal cell line. Endocrinology 114: 980–985

    PubMed  Google Scholar 

  51. Cole JA, Eber SL, Poelling RE, Thorne PK, Forte LR (1987) A dual mechanism for regulation of kidney phosphate transport by parathyroid hormone. Am J Physiol 253: (in press)

  52. Malmstrom K, Murer H (1986) Parathyroid hormone inhibits phosphate transport in OK cells but not in LLC-PK1 abd JTC-12.P3 cells. Am J Physiol 251: C23-C31

    PubMed  Google Scholar 

  53. Caverzasio J, Brown CDA, Biber J, Bonjour J-P, Murer H (1986) Sodium-dependent phosphate transport inhibited by parathyroid hormone and cyclic AMP stimulation in an opossum kidney cell line. J Biol Chem 261: 3233–3237

    PubMed  Google Scholar 

  54. Hruska KA, Goligorsky M, Scoble J, Tsutsumi M, Westbrook S, Moskowitz D (1986) Effects of parathyroid hormone on cytosolic calcium in renal proximal tubular primary cultures. Am J Physiol 251: F188-F198

    PubMed  Google Scholar 

  55. Hruska KA, Moskowitz D, Esbrit P, Civitelli R, Westbrook S, Huskey M (1987) Stimulation of inositol triphosphate and diacylglycerol production in renal tubular cells by parathyroid hormone. J Clin Invest 79: 230–239

    PubMed  Google Scholar 

  56. Brazy PC, Gullans SR, Mandel LJ, Dennis VW (1982) Metabolic requirement for inorganic phosphate by the rabbit proximal tubule. J Clin Invest 70: 53–62

    PubMed  Google Scholar 

  57. Bonjour J-P, Fleisch H (1980) Tubular adaptation to the supply and requirement of phosphate. In: Massry SG, Fleisch H (eds) Renal handling of phosphate. Plenum Press, New York, pp 243–264

    Google Scholar 

  58. Gloor HJ, Bonjour HP, Caverzasio J, Fleisch H (1979) Resistance to the phosphaturic and calcemic actions of parathyroid hormone during phosphate depletion. Prevention by 1,25-dihydroxy-vitamin D3. J Clin Invest 63: 371–377

    PubMed  Google Scholar 

  59. Pastoriza-Munoz E, Mishler DR, Lechene C (1983) Effect of phosphate deprivation on phosphate reabsorption in rat nephron: role of PTH. Am J Physiol 244: F140-F149

    PubMed  Google Scholar 

  60. Steele TH (1976) Renal resistance to parathyroid hormone during phosphate deprivation. J Clin Invest 58: 1461–1464

    PubMed  Google Scholar 

  61. Hruska KA, Hammerman MR (1981) Parathyroid hormone inhibition of phosphate transport in renal brush border vesicles from phosphate-depleted dogs. Biochim Biophys Acta 645: 351–356

    PubMed  Google Scholar 

  62. Czekalski S, Knox FG, Dousa TP (1982) Restoration of phosphaturic response to parathyroid hormone by glucocorticoid treatment in phosphorus-deprived rats. J Lab Clin Med 100: 858–865

    PubMed  Google Scholar 

  63. Berndt TJ, Knox FG, Kempson SA, Dousa TP (1981) Nicotinamide adenine dinucleotide and renal response to parathyroid hormone. Endocrinology 108: 2005–2007

    PubMed  Google Scholar 

  64. Hoppe A, Destro M, Knox FG (1980) Effect of NH4Cl on phosphaturic response to PTH in the hamster: dissociation from acidemia. Am J Physiol 239: E328-E332

    PubMed  Google Scholar 

  65. Caverzasio J, Bonjour J-P, Brown DA, Biber J, Murer H (1985) Adaptation of phosphate (Pi) transport in phosphate-deprived 2 LC-PKi cells. Am J Physiol 248: pp F122-F127

    PubMed  Google Scholar 

  66. Biber J, Brown CDA, Murer H (1983) Sodium-dependent transport of phosphate in LLC-PK1 cells. Biochim Biophys Acta 735: 325–330

    PubMed  Google Scholar 

  67. Noronha-Blob L, Filburn C, Sacktor B (1984) Phosphate uptake by kidney epithelial (LLC-PK1) cells. Arch Biochem Biophys 234: 265–274

    PubMed  Google Scholar 

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Hruska, K.A. Regulation of renal phosphate reabsorption: concepts in evolution. Pediatr Nephrol 1, 657–663 (1987). https://doi.org/10.1007/BF00853604

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