Measurement of peritoneal dialysis delivery in children
- 29 Downloads
We measured urea [weekly urea clearance/total body water (KT/Vurea)] and creatinine (CCr) clearances on 35 occasions in 15 stable chronic peritoneal dialysis patients to determine the feasibility and reproducibility of such measurements in children. In addition, we performed peritoneal equilibration tests (PETs) to characterize our patients' peritoneal membranes and to estimate weekly clearances. We demonstrated that dialysis delivery can be quantified by these standard measurements in children of widely varying size. Further, we found that clearances predicted from PET data were similar to measured values in all patients. However, predicted and measured values were most significantly correlated in patients with high and high-average peritoneal membrane permeability. KT/Vurea andCCr were correlated overall, but differences in scaling affected the validity of the relationship. When both clearances were scaled to weight, the correlation was closer, but still differed between PET-determined peritoneal membrane types.
key wordsPeritoneal dialysis Urea clearance Creatinine clearance Kinetic modeling
Unable to display preview. Download preview PDF.
- 2.Keshaviah PR, Nolph KD, Prowant B, Moore H, Ponferrade, L, Van Stone J, Twardowski ZJ, Khanna R (1990) Defining adequacy of CAPD with urea kinetics. In: Khanna R, Nolph KD, Prowant BF, Twardowski ZJ, Oreopoulos DG (eds) Advances in peritoneal dialysis vol 6. Peritoneal Dialysis International, Toronto, pp. 173–177Google Scholar
- 3.Twardowski ZJ (1989) New approaches to intermittent peritoneal dialysis therapies. In: Nolph KD (ed) Peritoneal dialysis, 3rd edn. Kluwer, Dordrecht, pp 133–151Google Scholar
- 7.Du Bois D, Du Bois EF (1916) A formula to estimate the approximate surface area if height and weight be known. Arch Intern Med 17: 863–871Google Scholar
- 9.Kohaut EC (1985) The effect of dialysate volume on ultrafiltration in young patients treated with CAPD. int J Pediatr. Nephrol 7: 13–16Google Scholar
- 11.Gruskin AB, Rosenblum H, Baluarte HJ, Morgenstern BZ, Polinsky MS, Perlman SA (1983) Transperitoneal solute movement in children. Kidney Int 24: S95-S100Google Scholar