Abstract
Humoral immunity was evaluated in seven children undergoing continuous ambulatory peritoneal dialysis (CAPD). Five children (71%) had serum immunoglobulin levels which were more than 2 SD below the mean for age. One mechanism contributing to hypogammaglobulinemia was loss via the peritoneal membrane. Daily losses of IgG into peritoneal dialysis effluents represented 7%–29% of normal daily IgG synthesis, and losses increased with duration of CAPD therapy. Despite the observed hypogammaglobulinemia, all children had protective antibody responses to immunization.
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Fivush, B.A., Case, B., May, M.W. et al. Hypogammaglobulinemia in children undergoing continuous ambulatory peritoneal dialysis. Pediatr Nephrol 3, 186–188 (1989). https://doi.org/10.1007/BF00852907
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DOI: https://doi.org/10.1007/BF00852907