Abstract
Sister chromatid exchange (SCE) analysis is the most sensitive method for assessing chromosome damage induced by chemical mutagens. We report the SCE of peripheral blood lymphocytes in children with primary nephrotic syndrome (NS) treated with chlorambucil. Group I consisted of 20 normal children, group 2 of 14 children with primary NS who had never received a cytotoxic drug and group III of 7 children with primary NS who had received chlorambucil, which was discontinued 6–36 months prior to the study. Group IV consisted of 4 nephrotic children who were receiving chlorambucil therapy during the study. There was no significant increase in SCE in group III compared with group I or group II (P≫0.05). A significant rise in SCE (P<0.05) was seen in all patients in group IV.
This is a preview of subscription content, log in via an institution to check access.
References
Williams SA, Makker SP, Ingelfinger JR, Grupe WE (1980) Long term assessment of chlorambucil plus prednisone in the idiopathic nephrotic syndrome of childhood. N Engl J Med 302: 929–933
Pascual JF, Molina M, Lopez J (1981) Long term assessment of chlorambucil in children with nephrotic syndrome who fail to respond adequately to corticosteroids. Contrib Nephrol 27: 65–74
Palmer RG, Denman AM (1984) Malignancies induced by chlorambucil. Cancer Treat Rev 11: 121–129
Palmer RG, Dore CJ, Denman AM (1984) Chlorambucil induced chromosome damage to human lymphocytes is dose dependent and cumulative. Lancet I: 246–249
Carcassonne Y, Gastaut JA, Blanc AP (1978) Acute leukemia after prolonged immunosuppressive therapy for glomerulonephritis. Cancer Treat Rep 62: 1110–1111
Kuis W, Kraker J de, Kingten RH, Donckerwolcke RA, Voute PA (1976) Acute lymphoblastic leukemia after treatment of nephrotic syndrome with immunosuppressive drugs. Helv Paediatr Acta 31: 91–95
Kleinknecht C, Guesry P, Lenoir G, Broyer M (1977) High-cost benefit of chlorambucil in frequently relapsing nephrosis. N Engl J Med 296: 48
Lenoir G, Guesry P, Kleinknecht C, Gagnadoux MF, Broyer M (1977) Complications extragonadiques du chlorambucil chez l'enfant a propos de 300 observations de nephropathies glomerulaires traitees. Arch Fr Pediatr 34: 798–807
Cap J, Misikova Z (1975) Chronisch-myeloische Leukämie als mögliche Folge immunsuppressiver Behandlung des nephrotischen Syndroms. Monatsschr Kinderheilkd 123: 718–720
Zimonyi I, Czirbesz Z, Dozsa M (1979) Orv Hetil 120: 37–38
Muller W, Brandis M (1981) Acute leukemia after cytotoxic treatment for non malignant disease in childhood. Eur J Pediatr 136: 105–108
Puri HC, Campbell RA (1977) Cyclophosphamide and malignancy. Lancet I: 1306
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Elzouki, A.Y., Al-Nassar, K., Al-Ali, M. et al. Sister chromatid exchange analysis in monitoring chlorambucil therapy in primary nephrotic syndrome of childhood. Pediatr Nephrol 5, 59–61 (1991). https://doi.org/10.1007/BF00852847
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00852847